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Hbb hemoglobin subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24440, updated on 25-Nov-2021

Summary

Official Symbol
Hbbprovided by RGD
Official Full Name
hemoglobin subunit betaprovided by RGD
Primary source
RGD:2783
See related
EnsemblRapid:ENSRNOG00000047098
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
beta-globin chain of hemoglobin, which binds and transports oxygen to peripheral tissues [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 320827.9), Lung (RPKM 72635.9) and 1 other tissue See more
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Genomic context

See Hbb in Genome Data Viewer
Location:
1q32
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158250421..158251832, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (168971269..168972680, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene beta globin minor gene Neighboring gene hemoglobin subunit beta-2 Neighboring gene hemoglobin subunit epsilon-like Neighboring gene hemoglobin subunit gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to haptoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables hemoglobin alpha binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hemoglobin alpha binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hemoglobin beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hemoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 
enables oxygen carrier activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oxygen transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxygen transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within oxygen transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme ISO
Inferred from Sequence Orthology
more info
 
involved_in renal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of hemoglobin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hemoglobin subunit beta-1
Names
III beta-1 globin
III beta-2 globin
beta-1-globin
hemoglobin beta chain complex
hemoglobin beta chain, major-form
hemoglobin beta-1 chain
hemoglobin, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033234.1NP_150237.1  hemoglobin subunit beta-1

    See identical proteins and their annotated locations for NP_150237.1

    Status: PROVISIONAL

    Source sequence(s)
    X16417
    UniProtKB/Swiss-Prot
    P02091
    Related
    ENSRNOP00000068726.2, ENSRNOT00000089125.2
    Conserved Domains (1) summary
    cd08925
    Location:7146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    158250421..158251832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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