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Zbtb38 zinc finger and BTB domain containing 38 [ Mus musculus (house mouse) ]

Gene ID: 245007, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb38provided by MGI
Official Full Name
zinc finger and BTB domain containing 38provided by MGI
Primary source
MGI:MGI:2442866
See related
Ensembl:ENSMUSG00000040433 AllianceGenome:MGI:2442866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIBZ; A930014K01Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and sequence-specific DNA binding activity. Predicted to be involved in cellular response to DNA damage stimulus and regulation of cellular macromolecule biosynthetic process. Predicted to be located in nucleoplasm. Is expressed in genitourinary system. Orthologous to human ZBTB38 (zinc finger and BTB domain containing 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 2.7), ovary adult (RPKM 2.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 50.71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96564820..96613728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96682767..96731675, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24963 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene RAS p21 protein activator 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96473690-96473991 Neighboring gene STARR-seq mESC enhancer starr_24966 Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene STARR-seq mESC enhancer starr_24967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96570433-96570620 Neighboring gene STARR-seq mESC enhancer starr_24971 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene STARR-positive B cell enhancer ABC_E9333 Neighboring gene STARR-seq mESC enhancer starr_24975 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96654988-96655289 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96659582-96659882 Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752 Neighboring gene STARR-seq mESC enhancer starr_24980 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene. Cai Y, et al. PLoS One, 2012. PMID 22427977, Free PMC Article
  2. The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression. Oikawa Y, et al. Cell Res, 2011 Nov. PMID 21625269, Free PMC Article
  3. Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor. Sasai N, et al. Genes Cells, 2005 Sep. PMID 16115196
  4. ZBTB38 is dispensable for antibody responses. Wong R, et al. PLoS One, 2020. PMID 32956421, Free PMC Article
  5. Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Ocskó T, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Nov. PMID 30343694

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.
    Title: Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.
  2. ZBTB38 is dispensable for antibody responses.
    Title: ZBTB38 is dispensable for antibody responses.
  3. Our studies demonstrate that Zbtb38 forms a molecular bridge between an arthritis-associated epimutation (DNA hypomethylation in Zbtb38 promoter) and transcriptional silencing of the IL1r2 gene in B cells. In this way, disease-associated DNA hypomethylation can support autoimmune arthritis by interfering with an anti-inflammatory pathway.
    Title: Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis.
  4. CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene.
    Title: CIBZ, a novel BTB domain-containing protein, is involved in mouse spinal cord injury via mitochondrial pathway independent of p53 gene.
  5. CIBZ post-transcriptionally regulates the expression of Nanog.
    Title: CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.
  6. CIBZ binds to a Myog promoter-proximal region and inhibits Myog transcription in a methylation-dependent manner.
    Title: The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression.
  7. CIBZ plays an important role by participating in the negative regulation of apoptosis in murine cells
    Title: Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 38
Names
CtBP-interacting BTB zinc finger protein
Zenon homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359959.1 → NP_001346888.1  zinc finger and BTB domain-containing protein 38

    Status: VALIDATED

    Source sequence(s)
    AC121951, AK054096
    Consensus CDS
    CCDS40731.1
    UniProtKB/TrEMBL
    Q3LR78
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001359960.1 → NP_001346889.1  zinc finger and BTB domain-containing protein 38

    Status: VALIDATED

    Source sequence(s)
    AC121951, AK054529
    Consensus CDS
    CCDS40731.1
    UniProtKB/TrEMBL
    Q3LR78
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_175537.3 → NP_780746.2  zinc finger and BTB domain-containing protein 38

    See identical proteins and their annotated locations for NP_780746.2

    Status: VALIDATED

    Source sequence(s)
    AC121951
    Consensus CDS
    CCDS40731.1
    UniProtKB/TrEMBL
    Q3LR78
    Related
    ENSMUSP00000091315.3, ENSMUST00000093798.9
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96564820..96613728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511191.5 → XP_006511254.1  zinc finger and BTB domain-containing protein 38 isoform X3

    See identical proteins and their annotated locations for XP_006511254.1

    UniProtKB/TrEMBL
    Q3LR78
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_036155015.1 → XP_036010908.1  zinc finger and BTB domain-containing protein 38 isoform X3

    UniProtKB/TrEMBL
    Q3LR78
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_006511189.5 → XP_006511252.1  zinc finger and BTB domain-containing protein 38 isoform X2

    Conserved Domains (6) summary
    sd00017
    Location:1029 → 1049
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1055 → 1077
    zf-C2H2; Zinc finger, C2H2 type
    cd18223
    Location:29 → 142
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam09507
    Location:725 → 955
    CDC27; DNA polymerase subunit Cdc27
    pfam13465
    Location:1042 → 1065
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:353 → 414
    zf-C2H2_8; C2H2-type zinc ribbon

  4. XM_006511193.5 → XP_006511256.1  zinc finger and BTB domain-containing protein 38 isoform X3

    See identical proteins and their annotated locations for XP_006511256.1

    UniProtKB/TrEMBL
    Q3LR78
    Conserved Domains (5) summary
    sd00017
    Location:1015 → 1035
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:15 → 128
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1041 → 1063
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1028 → 1051
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:340 → 400
    zf-C2H2_8; C2H2-type zinc ribbon

  5. XM_036155014.1 → XP_036010907.1  zinc finger and BTB domain-containing protein 38 isoform X1

    Conserved Domains (5) summary
    sd00017
    Location:1061 → 1081
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18223
    Location:61 → 174
    BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
    pfam00096
    Location:1087 → 1109
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1074 → 1097
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:386 → 446
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein Strain
Heading Accession and Version

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