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Dclk3 doublecortin-like kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 245038, updated on 23-Jun-2021

Summary

Official Symbol
Dclk3provided by MGI
Official Full Name
doublecortin-like kinase 3provided by MGI
Primary source
MGI:MGI:3039580
See related
Ensembl:ENSMUSG00000032500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dcamk; Dcamkl3; BC056929; C730036H08
Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]
Expression
Biased expression in kidney adult (RPKM 7.2), cortex adult (RPKM 6.3) and 13 other tissues See more
Orthologs
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Genomic context

See Dclk3 in Genome Data Viewer
Location:
9; 9 F3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111268149..111318679)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111439081..111489611)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (111341585..111392115)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene EPM2A (laforin) interacting protein 1 Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 36088 Neighboring gene src homology three (SH3) and cysteine rich domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase DCLK3
Names
CLICK-I and II-related
CLr
Click-I, -II related
doublecortin and CaM kinase-like 3
doublecortin-like and CAM kinase-like 3
NP_766516.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172928.5NP_766516.2  serine/threonine-protein kinase DCLK3

    See identical proteins and their annotated locations for NP_766516.2

    Status: REVIEWED

    Source sequence(s)
    AV341123, BB617821, DQ286388
    Consensus CDS
    CCDS23585.2
    UniProtKB/Swiss-Prot
    Q8BWQ5
    Related
    ENSMUSP00000107510.4, ENSMUST00000111879.5
    Conserved Domains (3) summary
    smart00220
    Location:514771
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl00155
    Location:92177
    UBQ; Ubiquitin-like proteins
    cl21453
    Location:513770
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    111268149..111318679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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