U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp354a zinc finger protein 354A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24522, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp354aprovided by RGD
Official Full Name
zinc finger protein 354Aprovided by RGD
Primary source
RGD:2967
See related
Ensembl:ENSRNOG00000003634 AllianceGenome:RGD:2967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kid1; Tcf17; Znf354a
Summary
Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nucleolar fragmentation; and response to folic acid. Located in nucleolus. Orthologous to human ZNF354A (zinc finger protein 354A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 130.4), Liver (RPKM 43.2) and 9 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35897217..35909063)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35396242..35408069)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (36586495..36600172)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480783 Neighboring gene olfactory receptor family 1 subfamily X member 2D Neighboring gene olfactory receptor family 1 subfamily N member 2 like, pseudogene 1 Neighboring gene uncharacterized LOC134480784 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102546326

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney. Yamato M, et al. J Recept Signal Transduct Res, 2009. PMID 19519174
  2. Differential expression of the zinc finger gene TCF17 in testicular tumors. Przyborski SA, et al. Cancer Res, 1998 Oct 15. PMID 9788609
  3. Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1. Witzgall R, et al. Genomics, 1994 Mar 15. PMID 8020966
  4. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Witzgall R, et al. Mol Cell Biol, 1993 Mar. PMID 8382778, Free PMC Article
  5. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus. Huang Z, et al. J Biol Chem, 1999 Mar 19. PMID 10075651

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. clock-controlled Kid-1 regulates the cell cycle of proliferating renal tubular epithelial cells through ERK phosphorylation.
    Title: Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in kidney development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to folic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 354A
Names
Kidney 1
TCF-17
kidney, ischemia, and developmentally-regulated protein 1
renal transcription factor Kid-1
transcription factor 17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052798.3 → NP_434685.1  zinc finger protein 354A

    See identical proteins and their annotated locations for NP_434685.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q02975
    UniProtKB/TrEMBL
    A6HE43
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:170 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    35897217..35909063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767660.4 → XP_008765882.1  zinc finger protein 354A isoform X1

    See identical proteins and their annotated locations for XP_008765882.1

    UniProtKB/TrEMBL
    Q6AZ27
    Related
    ENSRNOP00000092943.1
    Conserved Domains (5) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:169 → 566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:466 → 486
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:338 → 363
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039085190.2 → XP_038941118.1  zinc finger protein 354A isoform X2

    UniProtKB/TrEMBL
    A0A8L2QNR3
    Related
    ENSRNOP00000049437.4
    Conserved Domains (3) summary
    smart00349
    Location:14 → 56
    KRAB; krueppel associated box
    COG5048
    Location:137 → 534
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02975.1 GenPept UniProtKB/Swiss-Prot:Q02975

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous