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Mbl1 mannose-binding lectin (protein A) 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24548, updated on 3-Jan-2019

Summary

Official Symbol
Mbl1provided by RGD
Official Full Name
mannose-binding lectin (protein A) 1provided by RGD
Primary source
RGD:3055
See related
Ensembl:ENSRNOG00000011706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mbpa; Mlb1
Summary
N-terminal region has similarity to nonfibrillar collagens; C-terminal region, which includes the carbohydrate-binding domain, has similarity to the asialoglycoprotein receptor [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1232.3) See more

Genomic context

See Mbl1 in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (18736154..18742193)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (18604750..18610789)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene similar to phafin 2 Neighboring gene surfactant protein D Neighboring gene uncharacterized LOC102548312

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
    Complement and Coagulation Cascades, organism-specific biosystem
    Complement and Coagulation Cascades
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
polysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
complement activation, lectin pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation, lectin pathway IDA
Inferred from Direct Assay
more info
PubMed 
complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
growth plate cartilage chondrocyte morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
killing by host of symbiont cells IEA
Inferred from Electronic Annotation
more info
 
killing by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
negative regulation of growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
 
negative regulation of growth of symbiont in host ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mannose-binding protein A
Names
MBP-A
Mannose binding protein A, serum
mannan-binding protein
mannose binding lectin (A)
mannose binding lectin 1, protein A
mannose binding lectin 2, protein C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012599.2NP_036731.2  mannose-binding protein A precursor

    See identical proteins and their annotated locations for NP_036731.2

    Status: PROVISIONAL

    Source sequence(s)
    BC088159
    UniProtKB/Swiss-Prot
    P19999
    Related
    ENSRNOP00000015723.2, ENSRNOT00000015723.6
    Conserved Domains (2) summary
    cd03591
    Location:126236
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:3688
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    18736154..18742193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    17254917..17260956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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