Nexmif neurite extension and migration factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nexmifprovided by MGI
Official Full Name: neurite extension and migration factorprovided by MGI
Primary source: MGI:MGI:2148050
See related: Ensembl:ENSMUSG00000046449 AllianceGenome:MGI:2148050
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xpn; KIDLIA; A230051P11
Summary: Predicted to be involved in negative regulation of cell adhesion and negative regulation of neuron migration. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including midbody; mitotic spindle; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural tube mantle layer; sensory organ; skeleton; and tarsus. Used to study autism spectrum disorder and non-syndromic X-linked intellectual disability 98. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 98. Orthologous to human NEXMIF (neurite extension and migration factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 4.6), whole brain E14.5 (RPKM 2.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 46.48 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (103120367..103245403, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (104076761..104201783, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ale NEXMIF KO mice demonstrate reduced sociability and communication, elevated repetitive grooming behavior, and deficits in learning and memory. Loss of NEXMIF/KIDLIA expression results in a significant decrease in synapse density and synaptic protein expression. Male KO animals show aberrant synaptic function as measured by excitatory miniatures and postsynaptic currents in the hippocampus.
Title: NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function.
Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin.
Title: The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C77370 (e-PCR), detects polymorphism
- UniSTS:526851

px-44f10 (e-PCR)
- UniSTS:257820

RH36660 (e-PCR)
- UniSTS:85790

RH126153 (e-PCR)
- UniSTS:162865

RH126155 (e-PCR)
- UniSTS:162865

DXMit40 (e-PCR), detects polymorphism
- UniSTS:132148

DXMit158 (e-PCR), detects polymorphism
- UniSTS:132047

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurite extension and migration factor

Names: XLMR protein related to neurite extension

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077354.3 → NP_001070822.2 neurite extension and migration factor

See identical proteins and their annotated locations for NP_001070822.2

Status: VALIDATED

Source sequence(s)

AL671963

Consensus CDS

CCDS53166.1

UniProtKB/Swiss-Prot

Q003Y8, Q5DTT1, Q8BW26, Q8BYR0

UniProtKB/TrEMBL

Q003Y7

Related

ENSMUSP00000085187.5, ENSMUST00000087879.11

Conserved Domains (1) summary

pfam15735
Location:284 → 690

DUF4683; Domain of unknown function (DUF4683)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

103120367..103245403 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251340.2 → XP_030107200.1 neurite extension and migration factor isoform X1

UniProtKB/Swiss-Prot

Q003Y8, Q5DTT1, Q8BW26, Q8BYR0

UniProtKB/TrEMBL

Q003Y7

Conserved Domains (1) summary

pfam15735
Location:284 → 690

DUF4683; Domain of unknown function (DUF4683)
XM_006528031.5 → XP_006528094.1 neurite extension and migration factor isoform X1

See identical proteins and their annotated locations for XP_006528094.1

UniProtKB/Swiss-Prot

Q003Y8, Q5DTT1, Q8BW26, Q8BYR0

UniProtKB/TrEMBL

Q003Y7

Conserved Domains (1) summary

pfam15735
Location:284 → 690

DUF4683; Domain of unknown function (DUF4683)
XM_030251339.2 → XP_030107199.1 neurite extension and migration factor isoform X1

UniProtKB/Swiss-Prot

Q003Y8, Q5DTT1, Q8BW26, Q8BYR0

UniProtKB/TrEMBL

Q003Y7

Conserved Domains (1) summary

pfam15735
Location:284 → 690

DUF4683; Domain of unknown function (DUF4683)
XM_006528034.5 → XP_006528097.1 neurite extension and migration factor isoform X1

See identical proteins and their annotated locations for XP_006528097.1

UniProtKB/Swiss-Prot

Q003Y8, Q5DTT1, Q8BW26, Q8BYR0

UniProtKB/TrEMBL

Q003Y7

Conserved Domains (1) summary

pfam15735
Location:284 → 690

DUF4683; Domain of unknown function (DUF4683)