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Fat2 FAT atypical cadherin 2 [ Mus musculus (house mouse) ]

Gene ID: 245827, updated on 21-Apr-2024

Summary

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Official Symbol
Fat2provided by MGI
Official Full Name
FAT atypical cadherin 2provided by MGI
Primary source
MGI:MGI:2685369
See related
Ensembl:ENSMUSG00000055333 AllianceGenome:MGI:2685369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMI2; Fath2; Gm523; mKIAA0811
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-substrate adhesion; epithelial cell migration; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion. Predicted to be located in Golgi apparatus; cell junction; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; nose; and urinary system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 20.8) and bladder adult (RPKM 3.4) See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 32.5 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55141435..55228331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55250609..55337505, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr11:55017598-55017899 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_29532 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene secreted acidic cysteine rich glycoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Possible involvement of mitogen- and stress-activated protein kinase 1, MSK1, in metaphase-II arrest through phosphorylation of EMI2 in mouse oocytes. Miyagaki Y, et al. Dev Biol, 2011 Nov 1. PMID 21924255
  2. Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Rock R, et al. Dev Dyn, 2005 Nov. PMID 16059920
  3. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Barlow JL, et al. Nat Med, 2010 Jan. PMID 19966810, Free PMC Article
  4. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. Lodge EJ, et al. JCI Insight, 2020 Oct 27. PMID 33108146, Free PMC Article
  5. ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Capecchi MR, et al. Nat Commun, 2015 Nov 19. PMID 26581405, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin Fat 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029988.2 → NP_001025159.1  protocadherin Fat 2 precursor

    See identical proteins and their annotated locations for NP_001025159.1

    Status: PROVISIONAL

    Source sequence(s)
    AK132523, AK173031, AL713870
    Consensus CDS
    CCDS36157.1
    UniProtKB/Swiss-Prot
    Q3V1D4, Q5F226, Q69ZY7
    Related
    ENSMUSP00000104492.2, ENSMUST00000108864.2
    Conserved Domains (5) summary
    cd11304
    Location:3328 → 3424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:3953 → 3986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:3992 → 4022
    EGF; EGF-like domain
    cl29226
    Location:1883 → 1959
    Cadherin; Cadherin domain
    pfam02210
    Location:3802 → 3920
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55141435..55228331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533322.4 → XP_006533385.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533385.1

    UniProtKB/Swiss-Prot
    Q3V1D4, Q5F226, Q69ZY7
    Conserved Domains (5) summary
    cd11304
    Location:3328 → 3424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:3953 → 3986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:3992 → 4022
    EGF; EGF-like domain
    cl29226
    Location:1883 → 1959
    Cadherin; Cadherin domain
    pfam02210
    Location:3802 → 3920
    Laminin_G_2; Laminin G domain

  2. XM_030246003.1 → XP_030101863.1  protocadherin Fat 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3V1D4, Q5F226, Q69ZY7
    Related
    ENSMUSP00000067556.7, ENSMUST00000068853.13
    Conserved Domains (5) summary
    cd11304
    Location:3328 → 3424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:3953 → 3986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:3992 → 4022
    EGF; EGF-like domain
    cl29226
    Location:1883 → 1959
    Cadherin; Cadherin domain
    pfam02210
    Location:3802 → 3920
    Laminin_G_2; Laminin G domain

  3. XM_006533323.4 → XP_006533386.1  protocadherin Fat 2 isoform X1

    See identical proteins and their annotated locations for XP_006533386.1

    UniProtKB/Swiss-Prot
    Q3V1D4, Q5F226, Q69ZY7
    Conserved Domains (5) summary
    cd11304
    Location:3328 → 3424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:3953 → 3986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:3992 → 4022
    EGF; EGF-like domain
    cl29226
    Location:1883 → 1959
    Cadherin; Cadherin domain
    pfam02210
    Location:3802 → 3920
    Laminin_G_2; Laminin G domain

RNA

  1. XR_004936961.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F226.1 GenPept UniProtKB/Swiss-Prot:Q5F226

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