Amdhd2 amidohydrolase domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amdhd2provided by MGI
Official Full Name: amidohydrolase domain containing 2provided by MGI
Primary source: MGI:MGI:2443978
See related: Ensembl:ENSMUSG00000036820 AllianceGenome:MGI:2443978
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730457F11Rik
Summary: Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Is expressed in axial skeleton and nucleus pulposus. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 72.5), testis adult (RPKM 49.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.28 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24374807..24382752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24155833..24163733, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylgalactosamine-6-phosphate deacetylase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylglucosamine-6-phosphate deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine-6-phosphate deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylneuraminate catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylglucosamine-6-phosphate deacetylase

Names: amidohydrolase domain-containing protein 2; glcNAc 6-P deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase

NP_766523.2

EC 3.5.1.25

XP_036016505.1

EC 3.5.1.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172935.4 → NP_766523.2 N-acetylglucosamine-6-phosphate deacetylase

See identical proteins and their annotated locations for NP_766523.2

Status: PROVISIONAL

Source sequence(s)

CT010502

Consensus CDS

CCDS28475.1

UniProtKB/Swiss-Prot

Q8BK10, Q8JZV7

UniProtKB/TrEMBL

F7CUP3

Related

ENSMUSP00000036141.6, ENSMUST00000040735.12

Conserved Domains (2) summary

COG1228
Location:31 → 401

HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]

cd00854
Location:13 → 398

NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24374807..24382752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160612.1 → XP_036016505.1 N-acetylglucosamine-6-phosphate deacetylase isoform X1

UniProtKB/TrEMBL

F6UP77, F7CUP3

Related

ENSMUSP00000120520.3, ENSMUST00000129523.3

Conserved Domains (1) summary

cd00854
Location:13 → 442

NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...