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Wasf3 WASP family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 245880, updated on 9-Jan-2022

Summary

Official Symbol
Wasf3provided by MGI
Official Full Name
WASP family, member 3provided by MGI
Primary source
MGI:MGI:2658986
See related
Ensembl:ENSMUSG00000029636
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scar3; Wave3
Summary
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in lamellipodium and postsynapse. Is active in glutamatergic synapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 16.1) and 15 other tissues See more
Orthologs
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Genomic context

See Wasf3 in Genome Data Viewer
Location:
5; 5 G3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146321816..146410425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146385006..146473615)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (147196582..147282701)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52832 Neighboring gene predicted gene, 38747 Neighboring gene predicted gene 6408 Neighboring gene predicted gene 6370

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
wiskott-Aldrich syndrome protein family member 3
Names
WAS protein family, member 3
WASP family protein member 3
protein WAVE-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145155.3NP_660137.1  wiskott-Aldrich syndrome protein family member 3

    See identical proteins and their annotated locations for NP_660137.1

    Status: PROVISIONAL

    Source sequence(s)
    AC093356, AC115019
    Consensus CDS
    CCDS19870.1
    UniProtKB/Swiss-Prot
    Q8VHI6
    Related
    ENSMUSP00000016143.8, ENSMUST00000016143.9
    Conserved Domains (1) summary
    smart00246
    Location:439456
    WH2; Wiskott Aldrich syndrome homology region 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146321816..146410425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504834.3XP_006504897.1  wiskott-Aldrich syndrome protein family member 3 isoform X2

    Conserved Domains (1) summary
    smart00246
    Location:437454
    WH2; Wiskott Aldrich syndrome homology region 2
  2. XM_006504833.5XP_006504896.1  wiskott-Aldrich syndrome protein family member 3 isoform X1

    See identical proteins and their annotated locations for XP_006504896.1

    UniProtKB/Swiss-Prot
    Q8VHI6
    Conserved Domains (1) summary
    smart00246
    Location:439456
    WH2; Wiskott Aldrich syndrome homology region 2
  3. XM_030254506.2XP_030110366.1  wiskott-Aldrich syndrome protein family member 3 isoform X3

    Conserved Domains (1) summary
    smart00246
    Location:227244
    WH2; Wiskott Aldrich syndrome homology region 2

RNA

  1. XR_003955640.1 RNA Sequence

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