Npy neuropeptide Y [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Npyprovided by RGD
Full Name: neuropeptide Yprovided by RGD
Primary source: RGD:3197
See related: Ensembl:ENSRNOG00000046449 AllianceGenome:RGD:3197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPY02; RATNPY; RATNPY02
Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]
Expression: Biased expression in Spleen (RPKM 232.5), Brain (RPKM 130.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (80212111..80219310)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (78881294..78888495)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (79557856..79565059)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects.
Title: Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects.
Adolescent binge-like alcohol exposure dysregulates NPY and CGRP in rats: Behavioural and immunochemical evidence.
Title: Adolescent binge-like alcohol exposure dysregulates NPY and CGRP in rats: Behavioural and immunochemical evidence.
Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis.
Title: Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis.
Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.
Title: Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.
Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression.
Title: Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression.
Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL1betainduced extracellular matrix degradation.
Title: Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation.
Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus.
Title: Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus.
Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner.
Title: Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner.
Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats.
Title: Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats.
Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.
Title: Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.

Submit: New GeneRIF Correction See all GeneRIFs (252)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94574 (e-PCR)
- UniSTS:119822

d4mgh4 (e-PCR)
- UniSTS:121924

d4mit24 (e-PCR)
- UniSTS:121931

Npy (e-PCR), detects polymorphism
- UniSTS:527457

D4Arb35 (e-PCR), detects polymorphism
- UniSTS:227695

D4Arb7 (e-PCR), detects polymorphism
- UniSTS:227700

D4Hri1 (e-PCR)
- UniSTS:239736

D14Mit29 (e-PCR), detects polymorphism
- UniSTS:127386

D14Mit29.1 (e-PCR), detects polymorphism
- UniSTS:127387

D4Wox21 (e-PCR)
- UniSTS:117977

D6Kyo1 (e-PCR), detects polymorphism
- UniSTS:117977

D4Wox22 (e-PCR)
- UniSTS:117978

RH94804 (e-PCR)
- UniSTS:120050

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric oxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of nerve growth factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in short-day photoperiodism	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pro-neuropeptide Y

Names: pro-neuropeptide Y-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.