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Scd stearoyl-CoA desaturase [ Rattus norvegicus (Norway rat) ]

Gene ID: 246074, updated on 22-Aug-2021

Summary

Official Symbol
Scdprovided by RGD
Official Full Name
stearoyl-CoA desaturaseprovided by RGD
Primary source
RGD:621176
See related
Ensembl:ENSRNOG00000013552
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scd1
Summary
enzyme involved in the synthesis and regulation of unsaturated fatty acids [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues See more
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Genomic context

See Scd in Genome Data Viewer
Location:
1q54
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243269745..243282878, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264159966..264173061, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene stearoyl-coenzyme A desaturase 4 Neighboring gene 5S ribosomal RNA Neighboring gene Wnt family member 8B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-CoA 9-desaturase activity ISO
Inferred from Sequence Orthology
more info
 
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables stearoyl-CoA 9-desaturase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables stearoyl-CoA 9-desaturase activity ISO
Inferred from Sequence Orthology
more info
 
enables stearoyl-CoA 9-desaturase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in monounsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of water loss via skin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sebaceous gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in sterol esterification ISO
Inferred from Sequence Orthology
more info
 
involved_in tarsal gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-CoA desaturase 1
Names
delta(9)-desaturase 1
fatty acid desaturase 1
stearoyl-CoA desaturase 1
stearoyl-Coenzyme A desaturase 1
NP_631931.2
XP_006231495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139192.2NP_631931.2  acyl-CoA desaturase 1

    See identical proteins and their annotated locations for NP_631931.2

    Status: PROVISIONAL

    Source sequence(s)
    AF509569
    UniProtKB/Swiss-Prot
    P07308
    Related
    ENSRNOP00000018447.3, ENSRNOT00000018447.5
    Conserved Domains (2) summary
    cd03505
    Location:99336
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:100305
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    243269745..243282878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231433.3XP_006231495.1  acyl-CoA desaturase 1 isoform X1

    See identical proteins and their annotated locations for XP_006231495.1

    UniProtKB/Swiss-Prot
    P07308
    Conserved Domains (2) summary
    cd03505
    Location:99336
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:100305
    FA_desaturase; Fatty acid desaturase
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