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Uxs1 UDP-glucuronate decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246232, updated on 13-Apr-2024

Summary

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Official Symbol
Uxs1provided by RGD
Official Full Name
UDP-glucuronate decarboxylase 1provided by RGD
Primary source
RGD:628680
See related
Ensembl:ENSRNOG00000045605 AllianceGenome:RGD:628680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UGD
Summary
Enables UDP-glucuronate decarboxylase activity. Predicted to be involved in D-xylose metabolic process and UDP-D-xylose biosynthetic process. Located in Golgi apparatus. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 82.2), Thymus (RPKM 69.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uxs1 in Genome Data Viewer
Location:
9q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (740929..818310)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (653740..731121)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11165006..11240329, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480466 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ribosomal protein S8, pseudogene 14 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene zinc finger protein 119b like Neighboring gene ribosomal protein S21, pseudogene 2 Neighboring gene Epstein-Barr virus induced 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human UDP-α-d-xylose synthase forms a catalytically important tetramer that has not been observed in crystal structures. Polizzi SJ, et al. Biochemistry, 2013 Jun 4. PMID 23656592
  2. Human UDP-α-D-xylose synthase and Escherichia coli ArnA conserve a conformational shunt that controls whether xylose or 4-keto-xylose is produced. Polizzi SJ, et al. Biochemistry, 2012 Nov 6. PMID 23072385, Free PMC Article
  3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. Moriarity JL, et al. J Biol Chem, 2002 May 10. PMID 11877387
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
    Title: UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC93157

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables UDP-glucuronate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucuronate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucuronate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucuronate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-D-xylose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-D-xylose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-glucuronic acid decarboxylase 1
Names
UXS-1
NP_647552.2
XP_006244358.1
XP_008764973.1
XP_017451760.1
XP_017451761.1
XP_017451763.1
XP_038938947.1
XP_038938950.1
XP_038938951.1
XP_063122704.1
XP_063122705.1
XP_063122706.1
XP_063122708.1
XP_063122709.1
XP_063122710.1
XP_063122711.1
XP_063122712.1
XP_063122714.1
XP_063122715.1
XP_063122716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139336.2 → NP_647552.2  UDP-glucuronic acid decarboxylase 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5PQX0, Q8K464
    UniProtKB/TrEMBL
    A0A8I6AAA1, A6KR28
    Conserved Domains (2) summary
    cd05230
    Location:89 → 392
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:4 → 78
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    740929..818310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266642.1 → XP_063122712.1  UDP-glucuronic acid decarboxylase 1 isoform X13

  2. XM_063266635.1 → XP_063122705.1  UDP-glucuronic acid decarboxylase 1 isoform X2

  3. XM_063266646.1 → XP_063122716.1  UDP-glucuronic acid decarboxylase 1 isoform X12

  4. XM_063266636.1 → XP_063122706.1  UDP-glucuronic acid decarboxylase 1 isoform X3

  5. XM_063266645.1 → XP_063122715.1  UDP-glucuronic acid decarboxylase 1 isoform X12

  6. XM_006244296.5 → XP_006244358.1  UDP-glucuronic acid decarboxylase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AAA1, A0A8L2R317
    Related
    ENSRNOP00000070855.2
    Conserved Domains (2) summary
    cd05230
    Location:94 → 397
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:4 → 83
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  7. XM_039083023.2 → XP_038938951.1  UDP-glucuronic acid decarboxylase 1 isoform X14

    UniProtKB/TrEMBL
    A0A8L2QX18
    Conserved Domains (1) summary
    cd05230
    Location:1 → 284
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

  8. XM_039083022.2 → XP_038938950.1  UDP-glucuronic acid decarboxylase 1 isoform X15

    Conserved Domains (2) summary
    cd05230
    Location:24 → 271
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:4 → 31
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  9. XM_017596274.3 → XP_017451763.1  UDP-glucuronic acid decarboxylase 1 isoform X14

    UniProtKB/TrEMBL
    A0A8L2QX18
    Conserved Domains (1) summary
    cd05230
    Location:1 → 284
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

  10. XM_008766751.3 → XP_008764973.1  UDP-glucuronic acid decarboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8L2QX18
    Conserved Domains (3) summary
    cd05230
    Location:112 → 415
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    COG0451
    Location:112 → 419
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    pfam11803
    Location:48 → 101
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  11. XM_039083019.2 → XP_038938947.1  UDP-glucuronic acid decarboxylase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8L2QX18
    Conserved Domains (2) summary
    cd05230
    Location:107 → 410
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:48 → 96
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  12. XM_017596271.2 → XP_017451760.1  UDP-glucuronic acid decarboxylase 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6AIX5, A0A8L2QX18
    Related
    ENSRNOP00000094146.1, ENSRNOT00000094164.1
    Conserved Domains (2) summary
    cd05230
    Location:76 → 379
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:15 → 65
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  13. XM_017596272.3 → XP_017451761.1  UDP-glucuronic acid decarboxylase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8L2QX18
    Conserved Domains (2) summary
    cd05230
    Location:71 → 374
    UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    pfam11803
    Location:15 → 60
    UXS1_N; UDP-glucuronate decarboxylase N-terminal

  14. XM_063266634.1 → XP_063122704.1  UDP-glucuronic acid decarboxylase 1 isoform X1

  15. XM_063266638.1 → XP_063122708.1  UDP-glucuronic acid decarboxylase 1 isoform X6

  16. XM_063266639.1 → XP_063122709.1  UDP-glucuronic acid decarboxylase 1 isoform X7

  17. XM_063266641.1 → XP_063122711.1  UDP-glucuronic acid decarboxylase 1 isoform X12

  18. XM_063266640.1 → XP_063122710.1  UDP-glucuronic acid decarboxylase 1 isoform X9

  19. XM_063266644.1 → XP_063122714.1  UDP-glucuronic acid decarboxylase 1 isoform X16

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQX0.1 GenPept UniProtKB/Swiss-Prot:Q5PQX0

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