Plcd1 phospholipase C, delta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plcd1provided by RGD
Official Full Name: phospholipase C, delta 1provided by RGD
Primary source: RGD:3346
See related: Ensembl:ENSRNOG00000032238 AllianceGenome:RGD:3346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plc1
Summary: Enables several functions, including inositol 1,4,5 trisphosphate binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of norepinephrine secretion. Located in several cellular components, including cytosol; membrane raft; and mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 103.2), Muscle (RPKM 72.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (127672955..127695939, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (118795196..118818186, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (127753514..127782070, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that these phospholipase C delta-1 (PLCdelta1) mutations associated with hereditary leukonychia do not uniformly alter the enzymatic ability of this protein leading to loss/gain of function, but result in significantly divergent enzymatic properties.
Title: Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.
Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
Ca2+-independent binding of anionic phospholipids by phospholipase C delta1 EF-hand domain.
Title: Ca2+-independent binding of anionic phospholipids by phospholipase C δ1 EF-hand domain.
Phospholipase C delta 1 regulates interleukin-1beta and tumor necrosis factor-alpha mRNA expression.
Title: Phospholipase C-δ(1) regulates interleukin-1β and tumor necrosis factor-α mRNA expression.
the regeneration of white matter damaged by hypoperfusion is enhanced by inhibiting phosphodiesterase III
Title: Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain.
Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-delta1.
Title: Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-delta1.
PLC-delta(1) has multiple phosphorylation sites and phosphorylation status of PLC-delta(1) regulates its activity positively or negatively depends on the phosphorylation sites.
Title: Phosphorylation of phospholipase C-delta 1 regulates its enzymatic activity.
Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.
Title: Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.
PLC-delta1 and nuclear phospholipid metabolism have roles in regulating cyclin E and cell cycle progression
Title: Phospholipase C-delta1 expression is linked to proliferation, DNA synthesis, and cyclin E levels.
the FSH-induced Galphah/PLC-delta1 pathway-dependent Ca(2+) influx of rat SCs is mediated by T-type Ca(2+) channels and independent of in-store calcium release.
Title: Follicle-stimulating hormone-induced Galphah/phospholipase C-delta1 signaling mediating a noncapacitative Ca2+ influx through T-type Ca2+ channels in rat sertoli cells.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
NOT enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inositol trisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to aluminum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to prostaglandin F	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Names: PLC-III; PLC-delta-1; Phospholipase C-delta1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 long form; phospholipase C-III

NP_058731.2

EC 3.1.4.11

XP_006244125.1

EC 3.1.4.11

XP_038936754.1

EC 3.1.4.11

XP_038936755.1

EC 3.1.4.11

XP_038936756.1

EC 3.1.4.11

XP_038936757.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017035.2 → NP_058731.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5

UniProtKB/TrEMBL

A6I3V0, G3V9D1

Related

ENSRNOP00000042824.3, ENSRNOT00000045493.6

Conserved Domains (4) summary

cd00275
Location:628 → 755

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08593
Location:295 → 596

PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta

cd13363
Location:22 → 139

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

cd16217
Location:144 → 283

EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

127672955..127695939 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244063.5 → XP_006244125.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0I7, A6Y857

Related

ENSRNOP00000076591.1

Conserved Domains (7) summary

cd00275
Location:628 → 782

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08593
Location:295 → 596

PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta

PLN02952
Location:213 → 778

PLN02952; phosphoinositide phospholipase C

cd13363
Location:22 → 139

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:30 → 130

PH; PH domain

pfam09279
Location:213 → 295

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:159 → 208

EF-hand_10; EF hand
XM_039080826.2 → XP_038936754.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2

UniProtKB/Swiss-Prot

P10688, Q80WI4, Q9QVD3, Q9QVD4, Q9QVD5

UniProtKB/TrEMBL

A0A8I6GIK0

Related

ENSRNOP00000090035.1

Conserved Domains (4) summary

cd00275
Location:654 → 781

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08593
Location:321 → 622

PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta

cd13363
Location:48 → 165

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

cd16217
Location:170 → 309

EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
XM_039080828.1 → XP_038936756.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X4

Conserved Domains (3) summary

cd00275
Location:372 → 499

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08593
Location:39 → 340

PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta

pfam09279
Location:8 → 32

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
XM_039080829.2 → XP_038936757.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X5

Conserved Domains (3) summary

cd13363
Location:22 → 139

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

cd16217
Location:144 → 283

EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

cl14615
Location:295 → 430

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_039080827.2 → XP_038936755.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3

Conserved Domains (3) summary

cd13363
Location:48 → 165

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

cd16217
Location:170 → 309

EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

cl14615
Location:321 → 456

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily