Rgs13 regulator of G-protein signaling 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs13provided by MGI
Official Full Name: regulator of G-protein signaling 13provided by MGI
Primary source: MGI:MGI:2180585
See related: Ensembl:ENSMUSG00000051079 AllianceGenome:MGI:2180585
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within G protein-coupled receptor signaling pathway and negative regulation of G protein-coupled receptor signaling pathway. Located in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including Peyer's patch germinal center; gut; and immune system. Orthologous to human RGS13 (regulator of G protein signaling 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (144013083..144053240, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (144137386..144177372, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells
Title: p53 negatively regulates RGS13 protein expression in immune cells.
Rgs13 is strongly expressed in the germinal center regions of spleen, Peyer's patches, and thymic medulla, interacts with Gialpha and Gqalpha, and strongly inhibits both CXCL12- and CXCL13-induced signaling.
Title: RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rgs13 (e-PCR), detects polymorphism
- UniSTS:239147

Rgs13 (e-PCR), detects polymorphism
- UniSTS:528182

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.