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Mafk MAF bZIP transcription factor K [ Rattus norvegicus (Norway rat) ]

Gene ID: 246760, updated on 5-Mar-2024

Summary

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Official Symbol
Mafkprovided by RGD
Official Full Name
MAF bZIP transcription factor Kprovided by RGD
Primary source
RGD:628633
See related
Ensembl:ENSRNOG00000065794 AllianceGenome:RGD:628633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables RING-like zinc finger domain binding activity; transcription cis-regulatory region binding activity; and transcription coregulator binding activity. Involved in nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human MAFK (MAF bZIP transcription factor K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 82.6), Heart (RPKM 79.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19948473..19970351, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14834628..14856414, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16923989..16934706, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene proteasome assembly chaperone 3 Neighboring gene transmembrane protein 184A Neighboring gene uncharacterized LOC102546414 Neighboring gene integrator complex subunit 1 Neighboring gene MICAL-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. Töröcsik B, et al. J Neurosci, 2002 Oct 15. PMID 12388604, Free PMC Article
  2. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. Kotkow KJ, et al. Proc Natl Acad Sci U S A, 1996 Apr 16. PMID 8622968, Free PMC Article
  3. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Itoh K, et al. Biochem Biophys Res Commun, 1997 Jul 18. PMID 9240432
  4. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Nioi P, et al. Mol Cell Biol, 2005 Dec. PMID 16314513, Free PMC Article
  5. Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Ohta K, et al. Biochem J, 2007 Mar 15. PMID 17083329, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. during early hepatocarcinogenesis, aberrantly expressed MYST histone acetyltransferase 3 may induce glutathione S-transferase placental form expression through the Nrf2-mediated pathway
    Title: Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RING-like zinc finger domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor MafK
Names
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145673.2 → NP_663706.2  transcription factor MafK

    See identical proteins and their annotated locations for NP_663706.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070906
    UniProtKB/TrEMBL
    Q6IRI7, Q8K4B3
    Related
    ENSRNOT00000117128.1
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19948473..19970351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089073.2 → XP_038945001.1  transcription factor MafK isoform X1

    UniProtKB/TrEMBL
    Q6IRI7, Q8K4B3
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  2. XM_006248915.5 → XP_006248977.1  transcription factor MafK isoform X1

    See identical proteins and their annotated locations for XP_006248977.1

    UniProtKB/TrEMBL
    Q6IRI7, Q8K4B3
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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