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Rn45s 45S pre-ribosomal RNA [ Rattus norvegicus (Norway rat) ]

Gene ID: 24723, updated on 29-Feb-2024

Summary

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Gene symbol
Rn45s
Gene description
45S pre-ribosomal RNA
See related
Ensembl:ENSRNOG00000065988
Gene type
rRNA
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The sequences coding for ribosomal RNAs are present as rDNA repeating units distributed on the short arms of chromosomes 3, 11, and 12. A 45S rRNA which serves as the precursor for the 18S, 5.8S and 28S rRNA, is transcribed from each rDNA unit by RNA polymerase I. The number of rDNA repeating units varies between individuals and from chromosome to chromosome, although usually 30 to 40 repeats are found on each chromosome. These ribosomal repeating units are not currently annotated on the reference genome. This gene represents the portion of one rDNA repeat which encodes the 45S pre-ribosomal RNA transcript. [provided by RefSeq, Feb 2012]
Expression
Biased expression in Liver (RPKM 14377.5), Spleen (RPKM 13767.2) and 9 other tissues See more
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Genomic context

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See Rn45s in Genome Data Viewer
Location:
chromosome: 11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (268961..277639, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) Unplaced Scaffold NW_023637849.1 (61191..69866, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (46643222..46655563)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene 18S ribosomal RNA Neighboring gene uncharacterized LOC134481045 Neighboring gene 45S pre-ribosomal RNA like 2 Neighboring gene 18S ribosomal RNA Neighboring gene vomeronasal 2, receptor 116 like, pseudogene 38 Neighboring gene uncharacterized LOC108350980 Neighboring gene thioredoxin-like 4A, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of silver-stained nucleolus organizer regions (Ag-NORs) in 16 inbred strains of the Norway rat, Rattus norvegicus. Sasaki M, et al. Cytogenet Cell Genet, 1986. PMID 2420536
  2. Transcription initiation site of rat ribosomal DNA. Rothblum LI, et al. Nucleic Acids Res, 1982 Nov 25. PMID 6296773, Free PMC Article
  3. Primary and secondary structure of rat 28 S ribosomal RNA. Hadjiolov AA, et al. Nucleic Acids Res, 1984 Apr 25. PMID 6328433, Free PMC Article
  4. The nucleotide sequence of a rat 18 S ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18 S ribosomal ribonucleic acid. Chan YL, et al. J Biol Chem, 1984 Jan 10. PMID 6323401
  5. The structure of rat 28S ribosomal ribonucleic acid inferred from the sequence of nucleotides in a gene. Chan YL, et al. Nucleic Acids Res, 1983 Nov 25. PMID 6316273, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Other Names

  • 45S pre-rRNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046239.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    V01270
    Related
    ENSRNOT00000107120.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    268961..277639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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