Tac1 tachykinin, precursor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tac1provided by RGD
Official Full Name: tachykinin, precursor 1provided by RGD
Primary source: RGD:3807
See related: AllianceGenome:RGD:3807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TAC; PPTA3; Ppt5fl; RATPPTA3
Summary: Enables substance P receptor binding activity. Involved in several processes, including learning or memory; positive regulation of secretion; and positive regulation of synaptic transmission. Located in extracellular space and plasma membrane. Used to study central sleep apnea and pulmonary hypertension. Biomarker of colitis and respiratory syncytial virus infectious disease. Orthologous to human TAC1 (tachykinin precursor 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Restricted expression toward (RPKM 126.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (36645344..36653548)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (35679183..35687180)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (33638853..33646819)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.
Title: Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.
UVB irradiation induces contralateral changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal horn and lateral spinal nucleus.
Title: UVB irradiation induces contralateral changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal horn and lateral spinal nucleus.
Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus.
Title: Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus.
The tachykinin substance P increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. Blocking the NK-1 receptor prevents the occurrence of cortical spreading depression waves induced by substance P dissolved in aqua and prevents the ignition of cortical spreading depression waves by aqua alone.
Title: The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo.
findings suggest that both SP and TGFbeta-1 can stimulate tenocyte fibrogenic processes, albeit differently. TGFbeta-1 pathway signaling was involved in CCN2 production at all time points examined, while SP induced collagen type I production independently prior to the onset of signaling through the TGFbeta-1 pathway.
Title: Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes.
BM-EPCs along with SP promote the pericyte-like coverage of BM-MSCs on endothelial tubules possibly through the induction of PDGF-BB.
Title: Endothelial precursor cells stimulate pericyte-like coverage of bone marrow-derived mesenchymal stem cells through platelet-derived growth factor-BB induction, which is enhanced by substance P.
These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.
Title: Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells.
Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats
Title: Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation.
Inferior alveolar nerve injury did not change the expression of GluA1, GluA2 and CGRP, but increased the expression of TRPV1 and substance P.
Title: Neurochemical effects of photobiostimulation in the trigeminal ganglion after inferior alveolar nerve injury.
The expression and distribution of SP and NK1R along the brain-gut axis in neonatal maternal separation rat.
Title: Expression and distribution of SP and its NK1 receptor in the brain-gut axis in neonatal maternally separated rat model with visceral hypersensitivity.

Submit: New GeneRIF Correction See all GeneRIFs (120)

General gene information

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Markers

Tac1 (e-PCR), detects polymorphism
- UniSTS:480301

RH127708 (e-PCR)
- UniSTS:211018

RH136646 (e-PCR)
- UniSTS:218737

Tac1 (e-PCR), detects polymorphism
- UniSTS:507267

D4Wox30 (e-PCR)
- UniSTS:517823

D4Mgh31 (e-PCR)
- UniSTS:517843

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuromedin K receptor binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance P receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables substance P receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables substance P receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticosterone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, cholinergic	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protachykinin-1

Names: PPT; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001124768.1 → NP_001118240.1 protachykinin-1 isoform b precursor

See identical proteins and their annotated locations for NP_001118240.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).

Source sequence(s)

AA818532, M14312, M34184

UniProtKB/TrEMBL

A6IDW0
NM_001124769.1 → NP_001118241.1 protachykinin-1 isoform c precursor

See identical proteins and their annotated locations for NP_001118241.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c).

Source sequence(s)

AA818532, M34184, X56306

UniProtKB/TrEMBL

A6IDW1
NM_001124770.1 → NP_001118242.1 protachykinin-1 isoform d precursor

See identical proteins and their annotated locations for NP_001118242.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform d).

Source sequence(s)

AA818532, M34184

UniProtKB/TrEMBL

A6IDV9
NM_012666.2 → NP_036798.1 protachykinin-1 isoform a precursor

See identical proteins and their annotated locations for NP_036798.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AA818532, M15191, M34184

UniProtKB/Swiss-Prot

P06767, P08856, P08857, P22356, Q6LD93

UniProtKB/TrEMBL

A6IDV8