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Tap1 transporter 1, ATP binding cassette subfamily B member [ Rattus norvegicus (Norway rat) ]

Gene ID: 24811, updated on 30-Sep-2021

Summary

Official Symbol
Tap1provided by RGD
Official Full Name
transporter 1, ATP binding cassette subfamily B memberprovided by RGD
Primary source
RGD:3817
See related
EnsemblRapid:ENSRNOG00000000457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cim; Tap2; Abcb2
Summary
has similarity to multidrug resistant transporters; may transport antigenic peptides across the endoplasmic reticulum membrane in preparation for MHC class I presentation [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 337.5), Spleen (RPKM 282.5) and 9 other tissues See more
Orthologs
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Genomic context

See Tap1 in Genome Data Viewer
Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4656262..4666634, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3979302..3989669)

Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene transporter 2, ATP binding cassette subfamily B member Neighboring gene proteasome 20S subunit beta 8 Neighboring gene proteasome 20S subunit beta 9 Neighboring gene RT1 class II, locus DMb

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124549

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type peptide antigen transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type peptide antigen transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ABC-type peptide antigen transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type peptide antigen transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables ABC-type peptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ADP binding IEA
Inferred from Electronic Annotation
more info
 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MHC class I protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class Ib protein binding IEA
Inferred from Electronic Annotation
more info
 
enables MHC class Ib protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TAP1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables TAP2 binding IEA
Inferred from Electronic Annotation
more info
 
enables TAP2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tapasin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tapasin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent IEA
Inferred from Electronic Annotation
more info
 
involved_in cytosol to endoplasmic reticulum transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cytosol to endoplasmic reticulum transport ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen transport TAS
Traceable Author Statement
more info
PubMed 
involved_in peptide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protection from natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class I peptide loading complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of TAP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TAP complex IEA
Inferred from Electronic Annotation
more info
 
part_of TAP complex ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
antigen peptide transporter 1
Names
APT1
ATP-binding cassette sub-family B member 2
peptide transporter TAP1
transporter 1 ABC (ATP binding cassette)
transporter 1 ATP-binding cassette sub-family B
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032055.4NP_114444.2  antigen peptide transporter 1 precursor

    See identical proteins and their annotated locations for NP_114444.2

    Status: VALIDATED

    Source sequence(s)
    BC101854, BX883043, Y10234
    UniProtKB/TrEMBL
    P97561, P97949
    Related
    ENSRNOP00000000529.4, ENSRNOT00000000529.7
    Conserved Domains (3) summary
    TIGR00958
    Location:2717
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:177435
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:469697
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

    Range
    4656262..4666634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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