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Clu clusterin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24854, updated on 30-Sep-2021

Summary

Official Symbol
Cluprovided by RGD
Official Full Name
clusterinprovided by RGD
Primary source
RGD:3907
See related
EnsemblRapid:ENSRNOG00000016460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B
Summary
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
Expression
Biased expression in Heart (RPKM 3647.0), Liver (RPKM 1803.6) and 7 other tissues See more
Orthologs
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Genomic context

See Clu in Genome Data Viewer
Location:
15p12
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40161068..40200315)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42626612..42665858)

Chromosome 15 - NC_051350.1Genomic Context describing neighboring genes Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene glioma tumor suppressor candidate region gene 2 protein-like Neighboring gene coiled-coil domain containing 25 Neighboring gene scavenger receptor class A, member 3 Neighboring gene serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like Neighboring gene gulonolactone (L-) oxidase Neighboring gene uncharacterized LOC102555773 Neighboring gene ADAM metallopeptidase domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carrier activity IEA
Inferred from Electronic Annotation
more info
 
enables protein carrier activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding IEA
Inferred from Electronic Annotation
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system myelin maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system myelin maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system myelin maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune complex clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in immune complex clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in immune complex clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microglial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to thapsigargin IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cellular response to thapsigargin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to tunicamycin IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cellular response to tunicamycin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurofibrillary tangle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurofibrillary tangle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein import IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to misfolded protein IEA
Inferred from Electronic Annotation
more info
 
involved_in response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to misfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to potassium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in aggresome IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in chromaffin granule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neurofibrillary tangle IEA
Inferred from Electronic Annotation
more info
 
located_in neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
located_in neurofibrillary tangle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
clusterin
Names
dimeric acid glycoprotein
sulfated glycoprotein 2
testosterone repressed prostate message 2
testosterone-repressed prostate message
testostrone-repressed prostate message 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053021.3NP_444180.3  clusterin precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000270
    Related
    ENSRNOP00000072116.1, ENSRNOT00000078861.2
    Conserved Domains (1) summary
    pfam01093
    Location:29443
    Clusterin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051350.1 Reference mRatBN7.2 Primary Assembly

    Range
    40161068..40200315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252094.4XP_006252156.1  clusterin isoform X1

    See identical proteins and their annotated locations for XP_006252156.1

    UniProtKB/TrEMBL
    G3V836
    Related
    ENSRNOP00000075645.2, ENSRNOT00000091612.2
    Conserved Domains (1) summary
    pfam01093
    Location:29443
    Clusterin
  2. XM_039092999.1XP_038948927.1  clusterin isoform X2

    Conserved Domains (1) summary
    pfam01093
    Location:29443
    Clusterin
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