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Tbxas1 thromboxane A synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24886, updated on 30-Mar-2024

Summary

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Official Symbol
Tbxas1provided by RGD
Official Full Name
thromboxane A synthase 1provided by RGD
Primary source
RGD:3826
See related
Ensembl:ENSRNOG00000007918 AllianceGenome:RGD:3826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 48.4), Lung (RPKM 37.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (68631841..68803959)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (67664963..67837096)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66624181..66846745)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member L Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene uncharacterized LOC134486573 Neighboring gene lysine demethylase 7A Neighboring gene RNA, U6 small nuclear 604

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model. Minami D, et al. Cancer Sci, 2015 Oct. PMID 26211743, Free PMC Article
  2. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Kataoka M, et al. Am J Respir Crit Care Med, 2005 Dec 15. PMID 16192456
  3. Protective effect of FK506 and thromboxane synthase inhibitor on ischemia-reperfusion injury in non-heart-beating donor in rat orthotopic liver transplantation. Sasaki K, et al. J Med Invest, 2004 Feb. PMID 15000260
  4. Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. Imamura T, et al. Arzneimittelforschung, 2003. PMID 14650360
  5. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. Jones AE, et al. Am J Physiol Lung Cell Mol Physiol, 2003 Jun. PMID 12639842

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TBXAS1 gene expression was downregulated in rats with iron-induced mesothelioma.
    Title: Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydroperoxy icosatetraenoate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroperoxy icosatetraenoate dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables thromboxane-A synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thromboxane-A synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
thromboxane-A synthase
Names
TXA synthase
TXS
ThromboxA ane synthase 1
cytochrome P450 5A1
hydroperoxy icosatetraenoate dehydratase
thromboxane A synthase 1, platelet
NP_036819.1
XP_038963001.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012687.2 → NP_036819.1  thromboxane-A synthase

    See identical proteins and their annotated locations for NP_036819.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P49430
    UniProtKB/TrEMBL
    A6IET4
    Related
    ENSRNOP00000010796.2, ENSRNOT00000010796.5
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 530
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    68631841..68803959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107073.2 → XP_038963001.1  thromboxane-A synthase isoform X1

    Conserved Domains (1) summary
    cl41757
    Location:74 → 379
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49430.1 GenPept UniProtKB/Swiss-Prot:P49430

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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