Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2a1provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:2463
See related: Ensembl:ENSRNOG00000020817 AllianceGenome:RGD:2463
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Shdl; RATCYP2A1
Summary: Enables steroid hydroxylase activity. Involved in coumarin metabolic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3458.7) See more
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91359278..91372554)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82231611..82244887)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83711223..83725222)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that structures of active sites of CYP2A1 and CYP2A2 have certain amount of flexibility and that non-specific binding (i.e., hydrophobic binding) is involved in differences in substrate specificity between these two enzymes.
Title: Chimeric cDNA expression and site directed mutagenesis studies of cytochrome P450s CYP2A1 and CYP2A2.
the rat orthologue (CYP2A1) exhibits 3,4-epoxidation of coumarin
Title: Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Mco22 (e-PCR)
- UniSTS:240501

Cyp2a12 (e-PCR), detects polymorphism
- UniSTS:462988

D1Wox16 (e-PCR)
- UniSTS:117944

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in coumarin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coumarin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2A1

Names: CYPIIA1; P450-UT-F; cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1); cytochrome P450-UT-F; steroid hormones 7-alpha-hydroxylase; steroid hydroxylase, hepatic; testosterone 7-alpha-hydroxylase

NP_036824.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.