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Sult2a1 sulfotransferase family 2A member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24912, updated on 29-Feb-2024

Summary

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Official Symbol
Sult2a1provided by RGD
Official Full Name
sulfotransferase family 2A member 1provided by RGD
Primary source
RGD:621337
See related
Ensembl:ENSRNOG00000047986 AllianceGenome:RGD:621337
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
STa; St2; Sth2; Smp-2; St2a1
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and alcohol sulfotransferase activity. Involved in several processes, including cellular response to vitamin D; response to activity; and sulfation. Located in cytosol. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 6959.5) See more
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Genomic context

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Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (84582011..84639001, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (75451178..75508113, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (76558721..76614315, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nucleolin, pseudogene 3 Neighboring gene alcohol sulfotransferase-like Neighboring gene U6 spliceosomal RNA Neighboring gene signal recognition particle 72, pseudogene 1 Neighboring gene nucleolin, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon ACC) 2 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk. Kwon EM, et al. Cancer Epidemiol, 2012 Aug. PMID 22542949, Free PMC Article
  2. Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. Kim SY, et al. Drug Metab Dispos, 2005 Nov. PMID 16099924
  3. Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa. Apak TI, et al. Drug Metab Dispos, 2004 Dec. PMID 15371299
  4. Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Echchgadda I, et al. Mol Pharmacol, 2004 Mar. PMID 14978251
  5. Immunochemical characterisation of a dehydroepiandrosterone sulfotransferase in rats and humans. Sharp S, et al. Eur J Biochem, 1993 Feb 1. PMID 8436114

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that the physiological functions of SULT2A1 in different brain regions can be affected by methamphetamine.
    Title: Methamphetamine regulation of sulfotransferase 1A1 and 2A1 expression in rat brain sections.
  2. Data suggest that Sult2a1 and Sult1a1 can be induced in small intestinal mucosa by dietary factors (here, by various levels of caffeine); induction is gender specific and organ specific. Consumption of caffeine may enhance xenobiotic detoxification.
    Title: Caffeine induction of sulfotransferases in rat liver and intestine.
  3. there is a stress regulation mechanism of SULT2A1 at the gene transcription level, possibly occurring via hormones
    Title: Stress regulation of sulfotransferases in male rat liver.
  4. the SULT2A1 gene is mediated by SF1 and indirectly regulated by T(3)
    Title: Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alcohol sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables bile-salt sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile-salt sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables steroid sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to vitamin D IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ethanol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to activity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sulfotransferase 2A1
Names
ST
ST-20
alcohol sulfotransferase
bile salt sulfotransferase
bile-salt sulfotransferase 2A1
hydroxysteroid sulfotransferase a
hydroxysteroid sulfotransferase-like
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
sulfotransferase hydroxysteroid gene 2
sulfotransferase, hydroxysteroid preferring 2
NP_571978.1
XP_063137138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131903.1 → NP_571978.1  sulfotransferase 2A1

    See identical proteins and their annotated locations for NP_571978.1

    Status: PROVISIONAL

    Source sequence(s)
    D14987
    UniProtKB/TrEMBL
    A0A8L2R491
    Related
    ENSRNOP00000070596.2, ENSRNOT00000089371.2
    Conserved Domains (1) summary
    pfam00685
    Location:33 → 277
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    84582011..84639001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281068.1 → XP_063137138.1  sulfotransferase 2A1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133616.1: Suppressed sequence

    Description
    NM_133616.1: This RefSeq was permanently suppressed because it was based on a sequence from a different organism.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15709.4 GenPept UniProtKB/Swiss-Prot:P15709

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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