Eln elastin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elnprovided by RGD
Official Full Name: elastinprovided by RGD
Primary source: RGD:67394
See related: Ensembl:ENSRNOG00000001469 AllianceGenome:RGD:67394
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trela; TREL11; Trela26; RATTREL11
Summary: Enables extracellular matrix constituent conferring elasticity. Involved in several processes, including cellular response to L-ascorbic acid; cellular response to growth factor stimulus; and cellular response to lipid. Located in extracellular matrix and extracellular space. Used to study abdominal aortic aneurysm. Biomarker of autosomal recessive polycystic kidney disease; bladder neck obstruction; congenital diaphragmatic hernia; liver cirrhosis; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 2587.0), Heart (RPKM 1006.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27604983..27648413)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21968544..22011929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24978478..25021864)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-alpha/EGFR signaling promotes lipopolysaccharide-induced abnormal elastin deposition and alveolar simplification.
Title: TGF-α/EGFR signaling promotes lipopolysaccharide-induced abnormal elastin deposition and alveolar simplification.
Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2.
Title: Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2.
LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway.
Title: LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway.
Elastin levels are higher in healing tendons than in intact tendons and influence tissue compliance.
Title: Elastin levels are higher in healing tendons than in intact tendons and influence tissue compliance.
Expression of pulmonary arterial elastin in rats with hypoxic pulmonary hypertension using H2S.
Title: Expression of pulmonary arterial elastin in rats with hypoxic pulmonary hypertension using H2S.
Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.
Title: Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.
Elastic fibers were found to exhibit increase in tortuosity and fragmentation with increased pregnancies. Surprisingly, secondary structure, dynamics, and crosslinking of elastin from multiparous cohorts appear similar to healthy mammalian tissues, despite fragmentation observed at the fiber level.
Title: Alterations of elastin in female reproductive tissues arising from advancing parity.
Upregulation of nucleolin had an important role in Ang IIinduced vascular smooth muscle cell phenotypic transformation, and its underlying mechanism may be through interacting with tropoelastin mRNA, leading to its increased stability and protein expression.
Title: Nucleolin promotes Ang II‑induced phenotypic transformation of vascular smooth muscle cells via interaction with tropoelastin mRNA.
Overall, this study suggested that UC-MSCs could ameliorate aberrant elastin expression in the lung of hyperoxia-induced BPD model which may be associated with suppressing increased TGFbeta1 activation.
Title: Human umbilical cord-derived mesenchymal stem cells protect from hyperoxic lung injury by ameliorating aberrant elastin remodeling in the lung of O(2)-exposed newborn rat.
Effects on Mmp9 and Eln mRNA expression persisted with long-term SAA treatment, resulting in decreased insoluble elastin accumulation. These data reveal a novel mechanism whereby SAA and/or infection induce changes in vascular elastin consistent with atherosclerosis.
Title: Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix.

Submit: New GeneRIF Correction See all GeneRIFs (34)

General gene information

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Markers

Eln (e-PCR), detects polymorphism
- UniSTS:532485

BI274506 (e-PCR)
- UniSTS:249120

RH94685 (e-PCR)
- UniSTS:119932

Eln (e-PCR), detects polymorphism
- UniSTS:142983

D12Wox14 (e-PCR)
- UniSTS:517776

D12Hmgc2 (e-PCR)
- UniSTS:260792

D12Mgh12 (e-PCR)
- UniSTS:239829

D12Mgh13 (e-PCR)
- UniSTS:239830

Eln (e-PCR), detects polymorphism
- UniSTS:255219

D8Arb9 (e-PCR)
- UniSTS:239871

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix constituent conferring elasticity	IEA Inferred from Electronic Annotation more info
enables extracellular matrix constituent conferring elasticity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellular matrix constituent conferring elasticity	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aorta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in elastic fiber assembly	TAS Traceable Author Statement more info	PubMed
involved_in extracellular matrix assembly	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stress fiber assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in elastic fiber	IEA Inferred from Electronic Annotation more info
located_in elastic fiber	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elastin

Names: Tropoelastin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.