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Sds serine dehydratase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25044, updated on 31-Jul-2021

Summary

Official Symbol
Sdsprovided by RGD
Official Full Name
serine dehydrataseprovided by RGD
Primary source
RGD:67376
See related
Ensembl:ENSRNOG00000001388
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sdh; TDH; SDH2; Sdhe1; RATSDHE1
Summary
enzyme that converts L-serine to pyruvate and ammonia; involved in gluconeogenesis [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 90.4) and Kidney (RPKM 25.4) See more
Orthologs
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Genomic context

See Sds in Genome Data Viewer
Location:
12q16
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36083226..36090540, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41620429..41627741, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase-like Neighboring gene uncharacterized LOC108352452 Neighboring gene LIM homeobox 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC108581

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-serine ammonia-lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables L-serine ammonia-lyase activity TAS
Traceable Author Statement
more info
PubMed 
enables L-threonine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-serine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyruvate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyruvate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cobalamin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
L-serine dehydratase/L-threonine deaminase
Names
L-serine deaminase
L-threonine dehydratase
NP_446414.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053962.3NP_446414.3  L-serine dehydratase/L-threonine deaminase

    See identical proteins and their annotated locations for NP_446414.3

    Status: PROVISIONAL

    Source sequence(s)
    BC088110
    UniProtKB/Swiss-Prot
    P09367
    Related
    ENSRNOP00000001875.3, ENSRNOT00000001875.4
    Conserved Domains (1) summary
    cd06448
    Location:10320
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    36083226..36090540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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