Klrd1 killer cell lectin like receptor D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klrd1provided by RGD
Official Full Name: killer cell lectin like receptor D1provided by RGD
Primary source: RGD:2978
See related: Ensembl:ENSRNOG00000060246 AllianceGenome:RGD:2978
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd94
Summary: Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity; MHC protein complex binding activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; regulation of leukocyte mediated cytotoxicity; and stimulatory C-type lectin receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human KLRD1 (killer cell lectin like receptor D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 130.5), Lung (RPKM 72.0) and 6 other tissues See more
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Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164730833..164742539)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (163044920..163056568)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163358355..163369925)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rat CD94 coimmunoprecipitates with both DAP12 and DAP10 adaptor proteins.
Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables HLA-E specific inhibitory MHC class Ib receptor activity	IEA Inferred from Electronic Annotation more info
enables HLA-E specific inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein complex binding	IEA Inferred from Electronic Annotation more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein binding, via antigen binding groove	IEA Inferred from Electronic Annotation more info
enables MHC class Ib protein binding, via antigen binding groove	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein antigen binding	IEA Inferred from Electronic Annotation more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in natural killer cell mediated immunity	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natural killer cells antigen CD94

Names: CD94 antigen (located within the rat natural killer gene complex); killer cell lectin-like receptor, subfamily D, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012745.2 → NP_036877.1 natural killer cells antigen CD94

See identical proteins and their annotated locations for NP_036877.1

Status: PROVISIONAL

Source sequence(s)

BC086393

UniProtKB/Swiss-Prot

O35778

UniProtKB/TrEMBL

A0A8I6AHW6

Related

ENSRNOP00000074715.1, ENSRNOT00000082064.2

Conserved Domains (1) summary

cd03593
Location:61 → 176

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

164730833..164742539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237078.5 → XP_006237140.1 natural killer cells antigen CD94 isoform X1

UniProtKB/TrEMBL

A0A8I6AHW6

Conserved Domains (1) summary

cd03593
Location:52 → 153

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)