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Gnmt glycine N-methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25134, updated on 3-Feb-2019

Summary

Official Symbol
Gnmtprovided by RGD
Official Full Name
glycine N-methyltransferaseprovided by RGD
Primary source
RGD:2719
See related
Ensembl:ENSRNOG00000016349
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the conversion of S-adenosyl-L-methionine and glycine to S-adenosyl-L-homocysteine and sarcosine; involved in S-adenosylmethionine and folate metabolism [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 2226.4) See more
Orthologs

Genomic context

See Gnmt in Genome Data Viewer
Location:
9q12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16565274..16568626)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (15471889..15475241)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene pre T-cell antigen receptor alpha Neighboring gene canopy FGF signaling regulator 3 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene male-enhanced antigen 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
S-adenosyl-L-methionine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosyl-L-methionine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
folic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
folic acid binding TAS
Traceable Author Statement
more info
PubMed 
glycine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
glycine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
glycine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycine binding ISO
Inferred from Sequence Orthology
more info
 
glycine binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
S-adenosylhomocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylhomocysteine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylhomocysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
S-adenosylmethionine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylmethionine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylmethionine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
folic acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
glycine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
methionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
one-carbon metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homotetramerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
sarcosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcosine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
methyltransferase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycine N-methyltransferase
Names
folate-binding protein
glycine methyltransferase
NP_058780.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017084.1NP_058780.1  glycine N-methyltransferase

    See identical proteins and their annotated locations for NP_058780.1

    Status: PROVISIONAL

    Source sequence(s)
    X06150
    UniProtKB/Swiss-Prot
    P13255
    Related
    ENSRNOP00000022307.2, ENSRNOT00000022307.4
    Conserved Domains (1) summary
    pfam12847
    Location:60175
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    16565274..16568626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    12003123..12006473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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