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Lyz2 lysozyme 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25211, updated on 11-Apr-2024

Summary

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Official Symbol
Lyz2provided by RGD
Official Full Name
lysozyme 2provided by RGD
Primary source
RGD:3026
See related
Ensembl:ENSRNOG00000005825 AllianceGenome:RGD:3026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lyz; Lysz; Lyz1
Summary
Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 51113.8) and Spleen (RPKM 4301.1) See more
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Genomic context

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Location:
7q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54792715..54798060, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52906810..52912154, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60335968..60341264, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 9530003J23 Neighboring gene lysozyme C type 2 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093601

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of lead administration at low doses by different routes on rat spleens. Study of response of splenic lymphocytes and tissue lysozyme. Teijón C, et al. Toxicology, 2003 Sep 30. PMID 12965127
  2. Role of acid back-diffusion, glutathione, oxyradical, and histamine in antral hemorrhagic ulcer in rats: the protective effect of lysozyme chloride and antioxidants. Hung CR, et al. J Lab Clin Med, 2002 Sep. PMID 12271271
  3. Lysozyme expression in the rat parotid gland: light and electron microscopic immunogold studies. Staneva-Dobrovski L. Histochem Cell Biol, 1997 May. PMID 9208328
  4. Bactericidal activity of testicular macrophages. Wei RQ, et al. Biol Reprod, 1988 May. PMID 2840982
  5. Primary structure of rat lysozyme. White TJ, et al. Biochemistry, 1977 Apr 5. PMID 851497

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysozyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lysozyme activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rough endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysozyme C-1
Names
1,4-beta-N-acetylmuramidase C
NP_036903.2
XP_038934368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012771.3 → NP_036903.2  lysozyme C-1 precursor

    See identical proteins and their annotated locations for NP_036903.2

    Status: PROVISIONAL

    Source sequence(s)
    BC058490
    UniProtKB/Swiss-Prot
    P00697
    UniProtKB/TrEMBL
    A0A077S1I6, Q6PDV1
    Conserved Domains (1) summary
    smart00263
    Location:19 → 147
    LYZ1; Alpha-lactalbumin / lysozyme C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    54792715..54798060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078440.2 → XP_038934368.1  lysozyme C-1 isoform X1

    UniProtKB/TrEMBL
    F1M8E9
    Related
    ENSRNOP00000007747.5
    Conserved Domains (1) summary
    smart00263
    Location:19 → 191
    LYZ1; Alpha-lactalbumin / lysozyme C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00697.2 GenPept UniProtKB/Swiss-Prot:P00697

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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