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Tspy1 testis specific protein, Y-linked 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25223, updated on 13-Apr-2024

Summary

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Official Symbol
Tspy1provided by RGD
Official Full Name
testis specific protein, Y-linked 1provided by RGD
Primary source
RGD:3912
See related
Ensembl:ENSRNOG00000054648 AllianceGenome:RGD:3912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tspy
Summary
Enables histone binding activity. Involved in spermatogenesis. Located in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including TSPY10 (testis specific protein Y-linked 10); TSPY2 (testis specific protein Y-linked 2); and TSPY4 (testis specific protein Y-linked 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 16.6), Testes (RPKM 13.5) and 8 other tissues See more
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Genomic context

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Location:
Yq11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) Y NC_086040.1 (213710..218718, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) Y Unlocalized Scaffold NW_023637718.1 (200860..206429)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Y NC_024475.1 (151941..156587)

Chromosome Y - NC_086040.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 1, Y-linked Neighboring gene UPF0547 protein C16orf87 homolog pseudogene Neighboring gene uncharacterized LOC120099632 Neighboring gene mediator of RNA polymerase II transcription subunit 14-like Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Yin YH, et al. Br J Cancer, 2005 Aug 22. PMID 16106251, Free PMC Article
  2. Organization and expression of rat Tspy. Dechend F, et al. Cytogenet Cell Genet, 1998. PMID 10072602
  3. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Li Y, et al. Hum Pathol, 2007 Oct. PMID 17521702, Free PMC Article
  4. Detection of recurrent copy number loss at Yp11.2 involving TSPY gene cluster in prostate cancer using array-based comparative genomic hybridization. Vijayakumar S, et al. Cancer Res, 2006 Apr 15. PMID 16618725
  5. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Mazeyrat S, et al. Hum Mol Genet, 1998 Mar. PMID 9467017

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rat Tspy may play critical roles as a histone chaperone during maturation of the elongating spermatids in the rat testis
    Title: The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-specific Y-encoded protein 1
Names
Testis specific protein on Y
rTSPY
testis-specific protein TSPY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022923.2 → NP_075212.2  testis-specific Y-encoded protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000022
    UniProtKB/Swiss-Prot
    O70602, Q9R1M3, Q9R1M4
    UniProtKB/TrEMBL
    A0A8L2R474
    Related
    ENSRNOP00000075045.1, ENSRNOT00000083382.3
    Conserved Domains (1) summary
    cl08298
    Location:173 → 328
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086040.1 Reference GRCr8

    Range
    213710..218718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100721.2 → XP_038956649.1  testis-specific Y-encoded protein 1 isoform X2

    Related
    ENSRNOP00000081959.1
    Conserved Domains (1) summary
    cl08298
    Location:36 → 110
    NAP; Nucleosome assembly protein (NAP)

  2. XM_008773672.4 → XP_008771894.1  testis-specific Y-encoded protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008771894.1

    UniProtKB/Swiss-Prot
    O70602, Q9R1M3, Q9R1M4
    UniProtKB/TrEMBL
    A0A8L2R474
    Conserved Domains (1) summary
    cl08298
    Location:173 → 328
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_005498751.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1M3.2 GenPept UniProtKB/Swiss-Prot:Q9R1M3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous