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Fmo1 flavin containing dimethylaniline monoxygenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25256, updated on 5-Mar-2024

Summary

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Official Symbol
Fmo1provided by RGD
Official Full Name
flavin containing dimethylaniline monoxygenase 1provided by RGD
Primary source
RGD:2622
See related
Ensembl:ENSRNOG00000034191 AllianceGenome:RGD:2622
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RFMO1A
Summary
Enables N,N-dimethylaniline monooxygenase activity. Involved in response to lipopolysaccharide and response to osmotic stress. Located in intracellular membrane-bounded organelle. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1119.2), Lung (RPKM 550.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77715405..77747666, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75182184..75214439, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80712885..80745095, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene uncharacterized LOC134481577 Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 4 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 13 Neighboring gene flavin containing dimethylaniline monoxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. Li B, et al. Neurosci Lett, 2014 Apr 30. PMID 24440618
  2. Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Rodríguez-Fuentes G, et al. Toxicol Lett, 2009 Jun 1. PMID 19429252, Free PMC Article
  3. Hepatic flavin-containing monooxygenase activity attenuated by cGMP-independent nitric oxide-mediated mRNA destabilization. Ryu SD, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465034
  4. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Itoh K, et al. Biochim Biophys Acta, 1993 May 28. PMID 8504165
  5. Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Ekuni D, et al. Am J Pathol, 2009 Oct. PMID 19779138, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FMO, whose dysfunction could be a reason for the apoptosis of dopaminergic neurons in rotenone model, might be a new clue of pathological proteins in rotenone model of parkinsonism
    Title: Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism.
  2. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
    Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
  3. results suggest that nitric oxide acts directly in a cyclic GMP-independent mechanism by decreasing the half-life of flavin-containing monooxygenase 1 (FMO1) mRNA, thereby inducing impairment of FMO-related functions in endotoxemia
    Title: Hepatic flavin-containing monooxygenase activity attenuated by cGMP-independent nitric oxide-mediated mRNA destabilization.
  4. the relationship between gender and development in the expression of FMO1 in the liver and kidney was determined
    Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables hypotaurine dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables trimethylamine monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in taurine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
flavin-containing monooxygenase 1
Names
FMO 1
Flavin-containing monooxygenase 1
dimethylaniline monooxygenase [N-oxide-forming] 1
dimethylaniline oxidase 1
flavin containing monooxygenase 1
hepatic flavin-containing monooxygenase 1
trimethylamine monooxygenase
NP_036924.1
XP_006250207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012792.1 → NP_036924.1  flavin-containing monooxygenase 1

    See identical proteins and their annotated locations for NP_036924.1

    Status: PROVISIONAL

    Source sequence(s)
    M84719
    UniProtKB/TrEMBL
    A0A8L2R702
    Related
    ENSRNOP00000044613.1, ENSRNOT00000041908.4
    Conserved Domains (2) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:81 → 342
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77715405..77747666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250145.5 → XP_006250207.1  flavin-containing monooxygenase 1 isoform X1

    See identical proteins and their annotated locations for XP_006250207.1

    UniProtKB/Swiss-Prot
    P36365, Q6P7Q5
    UniProtKB/TrEMBL
    A0A8L2R702, A6IDA3
    Conserved Domains (2) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:81 → 342
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36365.2 GenPept UniProtKB/Swiss-Prot:P36365

Gene LinkOut

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