U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnah7 dynein, axonemal, heavy chain 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252893, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Dnah7provided by RGD
Official Full Name
dynein, axonemal, heavy chain 7provided by RGD
Primary source
RGD:621798
See related
Ensembl:ENSRNOG00000060984 AllianceGenome:RGD:621798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
axo b
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in cilium and cytosol. Predicted to be part of inner dynein arm. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 64.9), Lung (RPKM 39.9) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dnah7 in Genome Data Viewer
Location:
9q31
Exon count:
66
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (62454838..62760504, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (54960235..55266529, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60070087..60330121, complement) , (59564253..59595347, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 2 Neighboring gene uncharacterized LOC120094685 Neighboring gene solute carrier family 39 member 10 Neighboring gene uncharacterized LOC120094686 Neighboring gene serine/threonine kinase 17b Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. Zhang YJ, et al. J Biol Chem, 2002 May 17. PMID 11877439
  2. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
  3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner dynein arm assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm IEA
Inferred from Electronic Annotation
more info
  
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal heavy chain 7
Names
axonemal beta dynein heavy chain 7
axonemal dynein heavy chain b
ciliary dynein heavy chain 7
dynein heavy chain 7, axonemal
dynein, axonemal, heavy polypeptide 7
dynein-like protein 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419550.1 → NP_001406479.1  dynein axonemal heavy chain 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6A3H4, A0A8I6A4S9
    Related
    ENSRNOP00000085933.1, ENSRNOT00000106935.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    62454838..62760504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084571.2 → XP_038940499.1  dynein axonemal heavy chain 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4S9
    Conserved Domains (6) summary
    COG5245
    Location:933 → 3640
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:731 → 1136
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1264 → 1590
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2285 → 2547
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2937 → 3153
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3694 → 3994
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_039084570.2 → XP_038940498.1  dynein axonemal heavy chain 7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYD0, A0A8I6A4S9
    Related
    ENSRNOP00000070606.2
    Conserved Domains (6) summary
    COG5245
    Location:937 → 3644
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:735 → 1140
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1268 → 1594
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2289 → 2551
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2941 → 3157
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3698 → 3998
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_039084573.2 → XP_038940501.1  dynein axonemal heavy chain 7 isoform X3

    Conserved Domains (6) summary
    pfam17857
    Location:2151 → 2210
    AAA_lid_1; AAA+ lid domain
    pfam08393
    Location:756 → 1161
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1289 → 1615
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:1937 → 2117
    AAA_7; P-loop containing dynein motor region D3
    pfam17852
    Location:1781 → 1928
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    cl38936
    Location:1603 → 1746
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63170.2 GenPept UniProtKB/Swiss-Prot:Q63170

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials