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Cstb cystatin B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25308, updated on 6-May-2021

Summary

Official Symbol
Cstbprovided by RGD
Official Full Name
cystatin Bprovided by RGD
Primary source
RGD:2435
See related
Ensembl:ENSRNOG00000001201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyb; Epm1; Stfb
Summary
inhibits the activity of cathepsins B, H, L, and S; may protect against apoptosis that occurs in response to seizures [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 752.6), Kidney (RPKM 721.9) and 9 other tissues See more
Orthologs
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Genomic context

See Cstb in Genome Data Viewer
Location:
20p12
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10245462..10247505, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10966357..10968399, complement)

Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene similar to pyridoxal (pyridoxine, vitamin B6) kinase Neighboring gene pyridoxal kinase Neighboring gene ribosomal RNA processing 1 Neighboring gene uncharacterized LOC120098853

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Homology

Clone Names

  • MGC105499

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cystatin-B
Names
cystatin B (stefin B)
cystatin beta
liver thiol proteinase inhibitor
stefin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012838.2NP_036970.1  cystatin-B

    See identical proteins and their annotated locations for NP_036970.1

    Status: VALIDATED

    Source sequence(s)
    BC084725, CF976177
    UniProtKB/Swiss-Prot
    P01041
    Related
    ENSRNOP00000001593.2, ENSRNOT00000001593.4
    Conserved Domains (1) summary
    pfam00031
    Location:492
    Cystatin; Cystatin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

    Range
    10245462..10247505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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