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Ephx1 epoxide hydrolase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25315, updated on 13-Apr-2024

Summary

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Official Symbol
Ephx1provided by RGD
Official Full Name
epoxide hydrolase 1provided by RGD
Primary source
RGD:2557
See related
Ensembl:ENSRNOG00000003515 AllianceGenome:RGD:2557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mEH; MEH8
Summary
Enables cis-stilbene-oxide hydrolase activity; enzyme binding activity; and epoxide hydrolase activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 2589.7), Kidney (RPKM 779.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (95246079..95275852, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92714315..92744105, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (99271390..99300580, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481606 Neighboring gene left right determination factor 1 Neighboring gene transmembrane protein 63a Neighboring gene uncharacterized LOC120096328 Neighboring gene epoxide hydrolase 1-like Neighboring gene delta(4)-desaturase, sphingolipid 1 like 1 Neighboring gene ribosomal protein L35, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study. Makhlouf MM, et al. Biomarkers, 2016 Jul. PMID 26999617
  2. Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer. Khrunin AV, et al. Pharmacogenomics, 2014 Feb. PMID 24533712
  3. Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era. Martino A, et al. Cancer Epidemiol Biomarkers Prev, 2014 Apr. PMID 24521996
  4. High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. Chauhan PS, et al. Environ Mol Mutagen, 2012 Oct. PMID 22930568
  5. Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). Bonaventure A, et al. Cancer Causes Control, 2012 Feb. PMID 22200898

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury.
    Title: Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.
  2. involvement of PI3K signaling in regulation of ovarian xenobiotic metabolism by mEH.
    Title: Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling.
  3. The elevated expression of soluble epoxide hydrolase in kidney may play a role in high-salt induced hypertension.
    Title: [Renal over expression of soluble epoxide hydrolase in rat with hypertension induced by high-salt].
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cis-stilbene-oxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-stilbene-oxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cis-stilbene-oxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables cis-stilbene-oxide hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epoxide hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables epoxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxysterol binding IEA
Inferred from Electronic Annotation
more info
  
enables oxysterol binding ISO
Inferred from Sequence Orthology
more info
  
enables oxysterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in aromatic compound catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular aromatic compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to organic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in diol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
epoxide hydrolase 1
Names
epoxide hydratase
epoxide hydrolase 1 (microsomal xenobiotic hydrolase)
epoxide hydrolase 1, microsomal (xenobiotic)
liver microsomal xenobiotic epoxide hydrolase
microsomal epoxide hydrolase
NP_001029262.1
NP_036976.2
XP_038946306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034090.4 → NP_001029262.1  epoxide hydrolase 1

    See identical proteins and their annotated locations for NP_001029262.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P07687
    UniProtKB/TrEMBL
    A0A8L2R8K5, A6JGI7
    Related
    ENSRNOP00000034917.6, ENSRNOT00000029787.6
    Conserved Domains (2) summary
    pfam00561
    Location:142 → 401
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam06441
    Location:48 → 157
    EHN; Epoxide hydrolase N-terminus

  2. NM_012844.4 → NP_036976.2  epoxide hydrolase 1

    See identical proteins and their annotated locations for NP_036976.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P07687
    UniProtKB/TrEMBL
    A0A8L2R8K5, A6JGI7
    Related
    ENSRNOP00000004780.2, ENSRNOT00000004780.5
    Conserved Domains (2) summary
    pfam00561
    Location:142 → 401
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam06441
    Location:48 → 157
    EHN; Epoxide hydrolase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    95246079..95275852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090378.2 → XP_038946306.1  epoxide hydrolase 1 isoform X1

    UniProtKB/Swiss-Prot
    P07687
    UniProtKB/TrEMBL
    A0A8L2R8K5, A6JGI7
    Related
    ENSRNOP00000074206.2
    Conserved Domains (2) summary
    pfam00561
    Location:142 → 401
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam06441
    Location:48 → 157
    EHN; Epoxide hydrolase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07687.1 GenPept UniProtKB/Swiss-Prot:P07687

Gene LinkOut

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