Kcnc1 potassium voltage-gated channel subfamily C member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnc1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily C member 1provided by RGD
Primary source: RGD:2955
See related: Ensembl:ENSRNOG00000055401 AllianceGenome:RGD:2955
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv4; Kv3.1; KShIIIB; NGK2-KV4
Summary: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including brain development; positive regulation of voltage-gated potassium channel activity; and response to auditory stimulus. Located in several cellular components, including dendrite; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 66.9) and Muscle (RPKM 19.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106039247..106081034)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96902953..96944744)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (102414352..102456718)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trafficking-dependent roles of the Kv3.1b potassium channel are dependent on N229 site-specific glycosylation and N-glycan structure, and operate through a mechanism whereby specific N-glycan structures regulate cell surface expression.
Title: Identification and characterization of site-specific N-glycosylation in the potassium channel Kv3.1b.
This study demonstrated that Kv3.1b potassium channel expression in motor cortex pyramidal cells.
Title: Expression of Kv3.1b potassium channel is widespread in macaque motor cortex pyramidal cells: A histological comparison between rat and macaque.
Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent.
Title: Complex N-Glycans Influence the Spatial Arrangement of Voltage Gated Potassium Channels in Membranes of Neuronal-Derived Cells.
Results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels.
Title: Src regulates membrane trafficking of the Kv3.1b channel.
high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail.
Title: Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.
The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
Title: Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels.
Title: Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency.
These results have demonstrated that N-glycans of the Kv3.1 glycoprotein enhance outward ionic current kinetics, and neuronal migration.
Title: Importance of glycosylation on function of a potassium channel in neuroblastoma cells.
study to elucidate the relative distribution of Kv3.1b and Kv3.3 in specific compartments of the parallel fibers in the cerebellar cortex
Title: Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method.
A previously unknown interaction between the KV4 channel and Kv channel interacting protein (KChIP)3 in Muller cells could exert a physiological role in the onset of diabetic retinopathy.
Title: Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129997 (e-PCR)
- UniSTS:213285

BE106226 (e-PCR)
- UniSTS:246178

KCNC1_879 (e-PCR)
- UniSTS:277411

KCNC1_V172 (e-PCR)
- UniSTS:277411

RH27338 (e-PCR)
- UniSTS:85691

RH138274 (e-PCR)
- UniSTS:220361

Y07521 (e-PCR)
- UniSTS:125909

UniSTS:531455 (e-PCR)
- UniSTS:531455

Kcnc1 (e-PCR), detects polymorphism
- UniSTS:531455

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in globus pallidus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fibroblast growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nerve growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axolemma	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily C member 1

Names: NGK2; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); RAW2; potassium channel, voltage gated Shaw-related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012856.3 → NP_036988.1 potassium voltage-gated channel subfamily C member 1

See identical proteins and their annotated locations for NP_036988.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P25122

Related

ENSRNOP00000074146.1, ENSRNOT00000089488.2

Conserved Domains (2) summary

cd18414
Location:6 → 122

BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3

pfam00520
Location:189 → 447

Ion_trans; Ion transport protein