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LCLAT1 lysocardiolipin acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 253558, updated on 3-Apr-2024

Summary

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Official Symbol
LCLAT1provided by HGNC
Official Full Name
lysocardiolipin acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:26756
See related
Ensembl:ENSG00000172954 MIM:614241; AllianceGenome:HGNC:26756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2p23.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30447246..30644225)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30491581..30688529)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30670112..30867091)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15536 Neighboring gene uncharacterized LOC102723594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15537 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30517185-30517355 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30523745-30524427 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30524428-30525109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30525110-30525792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30525793-30526473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15543 Neighboring gene long intergenic non-protein coding RNA 1936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30633050-30633962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30666124-30666624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30669802-30670539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30670540-30671276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30738762-30739262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30739263-30739763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:30835819-30836816 Neighboring gene MPRA-validated peak3643 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15548 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:30874941-30875672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30875673-30876403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11329 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30943850-30944350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30944351-30944851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30988245-30988745 Neighboring gene calpain 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020137-31020846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020847-31021554 Neighboring gene uncharacterized LOC124905982 Neighboring gene uncharacterized LOC105374435

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics. Huang LS, et al. J Biol Chem, 2020 Sep 18. PMID 32732285, Free PMC Article
  2. The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Huang LS, et al. Am J Respir Crit Care Med, 2014 Jun 1. PMID 24779708, Free PMC Article
  3. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Wang C, et al. Blood, 2007 Nov 15. PMID 17675553, Free PMC Article
  4. Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation. Huang LS, et al. Free Radic Biol Med, 2017 Nov. PMID 28751023
  5. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. Zhao Y, et al. J Lipid Res, 2009 May. PMID 19075029, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
    Title: ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
  2. Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.
    Title: Long non-coding RNA DNMBP-AS1 promotes prostate cancer development by regulating LCLAT1.
  3. Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
    Title: Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
  4. LYCAT regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.
    Title: Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.
  5. LYCAT expression was significantly altered in PBMCs and lung tissues from patients with idiopathic pulmonary fibrosis.
    Title: The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
  6. Data show that ALCAT1 possesses acyltransferase activities toward lysophosphatidylinositol and lysophosphatidylglycerol, and identify critical amino acids that are potentially involved in lysophospholipid substrate binding.
    Title: The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiolipin acyl-chain remodeling TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
lysocardiolipin acyltransferase 1
Names
1-AGP acyltransferase 8
1-AGPAT 8
1-acylglycerol-3-phosphate O-acyltransferase 8
1ysophospholipid acyltransferase 6
acyl-CoA:lysocardiolipin acyltransferase 1
NP_001002257.1
NP_001291374.1
NP_001291375.1
NP_872357.2
XP_005264301.1
XP_005264302.1
XP_011531043.1
XP_016859235.1
XP_016859236.1
XP_047299824.1
XP_047299825.1
XP_054197237.1
XP_054197238.1
XP_054197239.1
XP_054197240.1
XP_054197241.1
XP_054197242.1
XP_054197243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002257.3 → NP_001002257.1  lysocardiolipin acyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001002257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC132154, BC146817, BX537607
    Consensus CDS
    CCDS42670.1
    UniProtKB/TrEMBL
    B4DYR5
    Related
    ENSP00000368823.3, ENST00000379509.8
    Conserved Domains (3) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7 → 286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234 → 306
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001304445.2 → NP_001291374.1  lysocardiolipin acyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001291374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC073255, AC132154, AK302562, BX537607
    Consensus CDS
    CCDS42670.1
    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7 → 286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234 → 306
    Acyltransf_C; Acyltransferase C-terminus

  3. NM_001304446.2 → NP_001291375.1  lysocardiolipin acyltransferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001291375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC132154, AK297262, BX537607
    UniProtKB/TrEMBL
    B4DM26
    Conserved Domains (2) summary
    cd07990
    Location:1 → 124
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:110 → 182
    Acyltransf_C; Acyltransferase C-terminus

  4. NM_182551.5 → NP_872357.2  lysocardiolipin acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_872357.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC132154, AY358702, BP872689, BX537607
    Consensus CDS
    CCDS1772.1
    UniProtKB/Swiss-Prot
    A6H8Z7, Q6UWP7, Q8N1Q7
    UniProtKB/TrEMBL
    B4DYR5
    Related
    ENSP00000310551.4, ENST00000309052.8
    Conserved Domains (3) summary
    cd07990
    Location:93 → 286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45 → 324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272 → 344
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    30447246..30644225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264245.4 → XP_005264302.1  lysocardiolipin acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_005264302.1

    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7 → 286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234 → 306
    Acyltransf_C; Acyltransferase C-terminus

  2. XM_005264244.2 → XP_005264301.1  lysocardiolipin acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005264301.1

    UniProtKB/Swiss-Prot
    A6H8Z7, Q6UWP7, Q8N1Q7
    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:93 → 286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45 → 324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272 → 344
    Acyltransf_C; Acyltransferase C-terminus

  3. XM_047443868.1 → XP_047299824.1  lysocardiolipin acyltransferase 1 isoform X2

  4. XM_017003746.2 → XP_016859235.1  lysocardiolipin acyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7 → 286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234 → 306
    Acyltransf_C; Acyltransferase C-terminus

  5. XM_047443869.1 → XP_047299825.1  lysocardiolipin acyltransferase 1 isoform X3

    Related
    ENSP00000368826.1, ENST00000319406.8

  6. XM_017003747.3 → XP_016859236.1  lysocardiolipin acyltransferase 1 isoform X4

  7. XM_011532741.3 → XP_011531043.1  lysocardiolipin acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011531043.1

    UniProtKB/Swiss-Prot
    A6H8Z7, Q6UWP7, Q8N1Q7
    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:93 → 286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45 → 324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272 → 344
    Acyltransf_C; Acyltransferase C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    30491581..30688529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341268.1 → XP_054197243.1  lysocardiolipin acyltransferase 1 isoform X2

  2. XM_054341262.1 → XP_054197237.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A6H8Z7, Q6UWP7, Q8N1Q7

  3. XM_054341264.1 → XP_054197239.1  lysocardiolipin acyltransferase 1 isoform X2

  4. XM_054341265.1 → XP_054197240.1  lysocardiolipin acyltransferase 1 isoform X2

  5. XM_054341266.1 → XP_054197241.1  lysocardiolipin acyltransferase 1 isoform X3

  6. XM_054341267.1 → XP_054197242.1  lysocardiolipin acyltransferase 1 isoform X4

  7. XM_054341263.1 → XP_054197238.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A6H8Z7, Q6UWP7, Q8N1Q7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWP7.1 GenPept UniProtKB/Swiss-Prot:Q6UWP7

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