Asic2 acid sensing ion channel subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asic2provided by RGD
Official Full Name: acid sensing ion channel subunit 2provided by RGD
Primary source: RGD:2017
See related: Ensembl:ENSRNOG00000058308 AllianceGenome:RGD:2017
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MDEG; Accn1; BNC1k; BNaC1; MDEG1; MDEG2
Summary: Enables voltage-gated sodium channel activity. Involved in several processes, including cellular response to acidic pH; positive regulation of cation channel activity; and sodium ion transport. Predicted to be located in dendritic spine and neuronal cell body. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 64.3), Kidney (RPKM 18.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (66368308..67438237, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65870592..66940577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (68247800..69347223, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats.
Title: A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats.
ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors.
Title: ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors.
Our findings identify PcTx1 as a valuable tool for studying ASIC1a/2a function and contribute significantly to the understanding of the diverse and complex pharmacology of PcTx1.
Title: Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a).
hippocampal glucose hypometabolism elevates ASIC2a expression by suppressing TFCP2 expression, which further enhances the intrinsic excitability of CA1 pyramidal neurons and increases seizure susceptibility in patients with temporal lobe epilepsy.
Title: Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
ASICs may enhance susceptibility to epileptogenesis in the piriform cortex.
Title: Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.
identified the expression and localization of different ASIC subunits in the rest and activated microglia and further elucidated the role of ASICs in microglia activation and inflammatory response
Title: Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.
identified domains of ASIC2 that are crucial to channel function and may be important for the function of other members of the ASIC family.
Title: Structural domains underlying the activation of acid-sensing ion channel 2a.
The aim of this study was to detect the expression of ASIC2 in the nasal septum in the embryonic stage of the rat.
Title: The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum.
These results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels.
Title: Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.
Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract
Title: Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

D11Bhm136 (e-PCR), detects polymorphism
- UniSTS:141573

D11Bhm137 (e-PCR), detects polymorphism
- UniSTS:141574

D10Got84 (e-PCR)
- UniSTS:112141

D10Rat210 (e-PCR), detects polymorphism
- UniSTS:226321

D10Chm228 (e-PCR)
- UniSTS:518175

d10arb27 (e-PCR)
- UniSTS:120614

D10Rat240 (e-PCR), detects polymorphism
- UniSTS:226350

BE108709 (e-PCR)
- UniSTS:247869

d10rat123 (e-PCR)
- UniSTS:120646

D10Rat28 (e-PCR), detects polymorphism
- UniSTS:226379

D10Mco1 (e-PCR)
- UniSTS:240459

AU047274 (e-PCR)
- UniSTS:110670

D10Rat70 (e-PCR), detects polymorphism
- UniSTS:226385

AU049558 (e-PCR)
- UniSTS:146005

D7Mit271 (e-PCR), detects polymorphism
- UniSTS:131169

D10Chm127 (e-PCR)
- UniSTS:518250

BE108934 (e-PCR)
- UniSTS:247924

D11Mit68.1 (e-PCR), detects polymorphism
- UniSTS:126615

D10Chm126 (e-PCR)
- UniSTS:518303

AU049121 (e-PCR)
- UniSTS:145569

BE106231 (e-PCR)
- UniSTS:246181

d10rat98 (e-PCR)
- UniSTS:120741

RH143882 (e-PCR)
- UniSTS:233128

D10Chm229 (e-PCR)
- UniSTS:518065

ha2237 (e-PCR)
- UniSTS:515513

D10Chm227 (e-PCR)
- UniSTS:518354

BF392929 (e-PCR)
- UniSTS:243695

BE119054 (e-PCR)
- UniSTS:249077

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion-gated channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion-gated channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phototransduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to acidic pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sour taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid-sensing ion channel 2

Names: BNC1; acid-sensing (proton-gated) ion channel 2; acid-sensing proton-gated ion channel 2 short variant MDEG2; amiloride-sensitive brain sodium channel 2; amiloride-sensitive cation channel 1, neuronal; brain sodium channel 1; degenerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034014.1 → NP_001029186.1 acid-sensing ion channel 2 isoform MDEG1

See identical proteins and their annotated locations for NP_001029186.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (MDEG1) uses an alternate 5' terminal exon compared to variant MDEG2. The resulting protein (isoform MDGEG1) is shorter and has a distinct N-terminus compared to isoform MDEG2.

Source sequence(s)

U53211

UniProtKB/Swiss-Prot

O55163, Q62962

UniProtKB/TrEMBL

A6HHC7

Related

ENSRNOP00000080191.1, ENSRNOT00000112270.1

Conserved Domains (1) summary

cl02990
Location:18 → 506

ASC; Amiloride-sensitive sodium channel
NM_012892.2 → NP_037024.2 acid-sensing ion channel 2 isoform MDEG2

See identical proteins and their annotated locations for NP_037024.2

Status: PROVISIONAL

Description

Transcript Variant: The variant (MDEG2) encodes the longer protein (isoform MDEG2).

Source sequence(s)

Y14635

UniProtKB/TrEMBL

A0A0G2JTM0, A6HHC8

Related

ENSRNOP00000068763.2, ENSRNOT00000086961.2

Conserved Domains (1) summary

TIGR00859
Location:64 → 557

ENaC; sodium channel transporter