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ssp2 serine/threonine protein kinase Ssp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539109, updated on 13-Mar-2024

Summary

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Gene symbol
ssp2
Gene description
serine/threonine protein kinase Ssp2
Primary source
PomBase:SPCC74.03c
Locus tag
SPCC74.03c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ucp9
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Genomic context

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See ssp2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003421.2 (1929190..1932004, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene rrm type RNA-binding protein Neighboring gene putative SNARE-binding protein Sly1 Neighboring gene cleavage and polyadenylation specificity factor complex-associated protein Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2. Chen Y, et al. Sci Rep, 2017 Jun 9. PMID 28600551, Free PMC Article
  2. Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress. Schutt KL, et al. Mol Biol Cell, 2017 Jul 1. PMID 28515144, Free PMC Article
  3. Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Qingyun, et al. Kobe J Med Sci, 2016 Aug 3. PMID 27604537, Free PMC Article
  4. Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe. Matsuzawa T, et al. Eukaryot Cell, 2012 Feb. PMID 22140232, Free PMC Article
  5. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Townley R, et al. Science, 2007 Mar 23. PMID 17289942

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of epe1 (+) impairs downstream events following phosphorylation of Ssp2, including nuclear translocation of Ssp2, sexual differentiation and inhibition of fatty acid synthesis. Our study reveals a novel way in which a jmjC-domain-containing protein regulates adaptive response by directly binding to a principal sensor.
    Title: Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2.
  2. results indicate that Ssp2 regulates phosphorylation and subcellular localization of Scr1 in response to glucose.
    Title: Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.
  3. Overexpression of the gsk3+ gene or the gsk31+ gene, another GSK3 member, rescues defective growth of Deltassp2 cells at restrictive temperatures and under glucose depletion as well as sexual differentiation under nitrogen depletion.
    Title: Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe.
  4. Nitrogen-stress-induced TORC1 inhibition differs from amino-acid-dependent control of TORC1 and requires the Ssp2 (AMPKalpha) kinase.
    Title: Nitrogen regulates AMPK to control TORC1 signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in induction of conjugation with cellular fusion EXP
Inferred from Experiment
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle switching, mitotic to meiotic cell cycle EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase Ssp2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1929190..1932004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023367.2 → NP_588376.1  serine/threonine protein kinase Ssp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588376.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74536
    UniProtKB/TrEMBL
    Q6LEP6
    Conserved Domains (4) summary
    smart00220
    Location:34 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14334
    Location:305 → 351
    UBA_SNF1_fungi; UBA domain of yeast carbon catabolite-derepressing protein kinases (Snf1) and similar proteins found in fungi
    cd14079
    Location:31 → 285
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    pfam16579
    Location:451 → 573
    AdenylateSensor; Adenylate sensor of SNF1-like protein kinase
Nucleotide Protein
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