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myo2 myosin II heavy chain myo2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539513, updated on 11-Apr-2024

Summary

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Gene symbol
myo2
Gene description
myosin II heavy chain myo2
Primary source
PomBase:SPCC645.05c
Locus tag
SPCC645.05c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rng5
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1233231..1238262, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene putative cardiolipin synthase PGP phosphatase domain-containing Gep4 Neighboring gene Fe-sulfur protein Isa1 Neighboring gene Smc5-6 complex non-SMC subunit Nse3 Neighboring gene RhoGEF Rgf3 Neighboring gene miscRNA Neighboring gene RhoGEF family guanine nucleotide exchange factor Rgf1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic suppression of defective profilin by attenuated Myosin II reveals a potential role for Myosin II in actin dynamics in vivo in fission yeast. Zambon P, et al. Mol Biol Cell, 2020 Sep 1. PMID 32614646, Free PMC Article
  2. Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint. Mulvihill DP, et al. J Cell Sci, 2002 Sep 15. PMID 12186944
  3. Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis. Malla M, et al. Mol Biol Cell, 2022 May 15. PMID 34613787, Free PMC Article
  4. Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly. Zimmermann D, et al. Nat Commun, 2017 Sep 26. PMID 28951543, Free PMC Article
  5. Motor Activity Dependent and Independent Functions of Myosin II Contribute to Actomyosin Ring Assembly and Contraction in Schizosaccharomyces pombe. Palani S, et al. Curr Biol, 2017 Mar 6. PMID 28238661, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic suppression of defective profilin by attenuated Myosin II reveals a potential role for Myosin II in actin dynamics in vivo in fission yeast.
    Title: Genetic suppression of defective profilin by attenuated Myosin II reveals a potential role for Myosin II in actin dynamics in vivo in fission yeast.
  2. Myo2p may function in two different and essential modes during cytokinesis: a motor activity-independent form that can promote actomyosin ring assembly and a motor activity-dependent form that supports ring contraction.
    Title: Motor Activity Dependent and Independent Functions of Myosin II Contribute to Actomyosin Ring Assembly and Contraction in Schizosaccharomyces pombe.
  3. Myo2 role in the Cdc12-associated actin filaments actomyosin ring assembly.
    Title: Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.
  4. Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction.
    Title: Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.
  5. Data show that contractile ring assembly is delayed in Myo2p motor and tropomyosin mutants, but occurs prematurely in cells engineered to express two copies of myo2.
    Title: Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast.
  6. Results describe the role of regulatory light-chain (Rlc1p) and heavy-chain phosphorylation in controlling fission yeast myosin-II (Myo2p) motor activity and function during cytokinesis.
    Title: Regulation of fission yeast myosin-II function and contractile ring dynamics by regulatory light-chain and heavy-chain phosphorylation.
  7. Analyses of Myo2p, Swo1p, and the UCS domain protein Rng3p establish that Swo1p and Rng3p collaborate in vivo to modulate myosin II function.
    Title: Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.
  8. Rng3p activates actin filament gliding by fission yeast myosin-II
    Title: UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity EXP
Inferred from Experiment
more info
 PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle transport along actin filament IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortical node IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, distal actin filament layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, proximal layer IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin II heavy chain myo2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1233231..1238262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023104.2 → NP_588114.1  myosin II heavy chain myo2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588114.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78969, Q9USI6
    Conserved Domains (3) summary
    COG5022
    Location:6 → 1516
    COG5022; Myosin heavy chain [General function prediction only]
    cd01377
    Location:91 → 743
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:25 → 48
    Myosin_N; Myosin N-terminal SH3-like domain
Nucleotide Protein
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