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cdc10 MBF transcription factor complex subunit Cdc10 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540234, updated on 11-Apr-2024

Summary

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Gene symbol
cdc10
Gene description
MBF transcription factor complex subunit Cdc10
Primary source
PomBase:SPBC336.12c
Locus tag
SPBC336.12c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2760741..2763830, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene protein Spc24 Neighboring gene RNA polymerase I upstream activation factor complex subunit Rrn7 Neighboring gene putative translation elongation factor eIF5A Neighboring gene putative GARP complex subunit Vps52 Neighboring gene miscRNA Neighboring gene putative endopeptidase catalytic subunit Neighboring gene miscRNA Neighboring gene PAN complex subunit Ppk26

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. Uzawa S, et al. Mol Biol Cell, 2004 Dec. PMID 15385623, Free PMC Article
  2. Cdc18 transcription and proteolysis couple S phase to passage through mitosis. Baum B, et al. EMBO J, 1998 Oct 1. PMID 9755169, Free PMC Article
  3. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. Yamano H, et al. EMBO J, 1996 Oct 1. PMID 8895572, Free PMC Article
  4. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Saka Y, et al. Cell, 1993 Jul 30. PMID 8343962
  5. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. Hofmann JF, et al. EMBO J, 1994 Jan 15. PMID 8313888, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Chk1 phosphorylates Cdc10 and inactivates MluI-binding factor (MBF)-dependent transcription.
    Title: The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.
  2. MBF dependent transcription remains active when Yox1 is phosphorylated and continues until cells are able to overcome this challenge
    Title: Yox1 links MBF-dependent transcription to completion of DNA synthesis.
  3. Results show that in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G(1)/S transcriptional program by directly regulating Cdc10 subunit of MBF, the G(1)/S transcription factor.
    Title: The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.
  4. identified a mechanism by which Cdc10p controls rDNA gene expression, therefore linking the cell cycle with cellular growth
    Title: Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production.
  5. There may be an S-phase-specific inhibitor of spindle pole body maturation whose expression is under control of cdc10(+)
    Title: Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific TAS
Traceable Author Statement
more info
 PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of MBF transcription complex EXP
Inferred from Experiment
more info
 PubMed 
part_of MBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MBF transcription complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in nucleus EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
MBF transcription factor complex subunit Cdc10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2760741..2763830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022050.2 → NP_596132.1  MBF transcription factor complex subunit Cdc10 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596132.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P01129, Q9UU04
    Conserved Domains (4) summary
    cd00204
    Location:387 → 519
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam04383
    Location:82 → 150
    KilA-N; KilA-N domain
    pfam12796
    Location:449 → 514
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:390 → 424
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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