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mcp5 dynein-anchoring factor Mcp5/Num1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540712, updated on 17-May-2024

Summary

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Gene symbol
mcp5
Gene description
dynein-anchoring factor Mcp5/Num1
Primary source
PomBase:SPBC216.02
Locus tag
SPBC216.02
See related
FungiDB:SPBC216.02; VEuPathDB:SPBC216.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mug21; num1
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Genomic context

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See mcp5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (898070..901363)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene putative squalene monooxygenase Erg1 Neighboring gene putative DNA damage response protein Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene putative methionine sulfoxide Neighboring gene ATR checkpoint kinase Rad3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance. Chacko LA, et al. J Cell Biol, 2019 Nov 4. PMID 31582398, Free PMC Article
  2. Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast. Saito TT, et al. J Cell Biol, 2006 Apr 10. PMID 16585273, Free PMC Article
  3. Fission yeast myosin I facilitates PI(4,5)P(2)-mediated anchoring of cytoplasmic dynein to the cortex. Thankachan JM, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28292899, Free PMC Article
  4. Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase. Yamashita A, et al. Genetics, 2006 Jul. PMID 16624923, Free PMC Article
  5. A conserved mechanism for mitochondria-dependent dynein anchoring. Kraft LM, et al. Mol Biol Cell, 2019 Mar 1. PMID 30649994, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance
    Title: Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.
  2. Dynein anchoring is established by cooperation of transient assembly of dynactin and function of Num1 at the cell cortex.
    Title: Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to cytoskeletal protein-membrane anchor activity EXP
Inferred from Experiment
more info
 PubMed 
enables cytoskeletal protein-membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeletal protein-membrane anchor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mitochondrion-plasma membrane adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitochondrion localization EXP
Inferred from Experiment
more info
 PubMed 
involved_in horsetail-astral microtubule organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in horsetail-astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in cell cortex IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane, cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein-anchoring factor Mcp5/Num1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    898070..901363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021261.2 → NP_595354.1  dynein-anchoring factor Mcp5/Num1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595354.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7J9
    Conserved Domains (1) summary
    pfam12814
    Location:840 → 959
    Mcp5_PH; Meiotic cell cortex C-terminal pleckstrin homology
Nucleotide Protein
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