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swi1 replication fork protection complex subunit Swi1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540728, updated on 20-May-2024

Summary

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Gene symbol
swi1
Gene description
replication fork protection complex subunit Swi1
Primary source
FungiDB:SPBC216.06c
Locus tag
SPBC216.06c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See swi1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (907370..914892, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative methionine sulfoxide Neighboring gene ATR checkpoint kinase Rad3 Neighboring gene phosphatidylinositol kinase Tor2 Neighboring gene protein Cwf11 Neighboring gene miscRNA Neighboring gene putative glutamyl-tRNA amidotransferase alpha subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Swi1 ensures telomere replication by suppressing recombination and repeat instability at telomeres. Our studies may also be relevant in understanding the potential role of Swi1 in regulation of telomere stability in cancer cells
    Title: Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.
  2. Swi1 associates with chromatin through its DDT domain and recruits Swi3 to function together as the replication fork protection complex
    Title: Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.
  3. Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
    Title: Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
  4. Swi1, the TIMELESS homologue, differentially controls the recombination potential of replication fork barriers, switching between being a suppressor and an activator of recombination in a site-specific fashion.
    Title: Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1.
  5. RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast.
    Title: RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
  6. Hsk1-Dfp1/Him1 and Swi1-Swi3 complexes have interrelated roles in stabilization of arrested replication forks
    Title: Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
  7. Swi1, Swi3, and Hsk1 act in a novel S-phase checkpoint pathway that contributes to replication fork maintenance and to survival of alkylation damage.
    Title: Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.
  8. Results support the notion that Swi1p and Swi3p act at several different protein-DNA complexes in the rDNA spacer regions to arrest replication but that not all fork barriers require their activity to arrest forks. [swi1]
    Title: swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Y-form DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gene conversion at mating-type locus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork arrest IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of replication fork protection complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
replication fork protection complex subunit Swi1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    907370..914892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021265.2 → NP_595358.1  replication fork protection complex subunit Swi1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595358.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UUM2, Q9Y7X0
    Conserved Domains (2) summary
    pfam05029
    Location:595 → 956
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:26 → 278
    TIMELESS; Timeless protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials