cdc13 G2/M B-type cyclin Cdc13 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: cdc13
Gene description: G2/M B-type cyclin Cdc13
Primary source: PomBase:SPBC582.03
Locus tag: SPBC582.03
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc13 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003423.3 (420076..423276)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study presents evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription; show that Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter thereby preventing Atf1-mediated mitotic acceleration; also show that this opposition of Atf1 functions by Pcr1 extends to the G1-S transition event
Title: Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.
Data suggest that Cdc2 is a likely client for the Cdc37 molecular chaperone, and that inactivation of Cdc2 appears to result from the inability to form complexes with its mitotic cyclin partner Cdc13.
Title: Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.
Cdc13p accumulates in the nucleolus in response to G(2) checkpoint delays, rather than in the cytoplasm, and that phosphorylation plays no role in Cdc13p localization or function
Title: Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function.
Mes1p is a factor that suppresses the degradation of cyclin Cdc13p at anaphase I
Title: Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
regulation of Cdc13p and Cdc2p is required for G2 arrest in splicing mutants of S. pombe
Title: Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA damage checkpoint signaling	EXP Inferred from Experiment more info	PubMed
involved_in mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic sister chromatid biorientation	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of mitotic sister chromatid biorientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, telomeric repeat region	EXP Inferred from Experiment more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	EXP Inferred from Experiment more info	PubMed
is_active_in mitotic spindle	HDA more info	PubMed
is_active_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle midzone	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in mitotic spindle pole body	EXP Inferred from Experiment more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in new mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear periphery	EXP Inferred from Experiment more info	PubMed
is_active_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolar peripheral inclusion body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in old mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/M B-type cyclin Cdc13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

420076..423276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001355823.1 → NP_001342891.1 G2/M B-type cyclin Cdc13 [Schizosaccharomyces pombe]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P10815, Q9UU16

Conserved Domains (1) summary

COG5024
Location:5 → 454

COG5024; Cyclin [Cell division and chromosome partitioning]