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sty1 MAP kinase Sty1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541652, updated on 11-Apr-2024

Summary

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Gene symbol
sty1
Gene description
MAP kinase Sty1
Locus tag
SPAC24B11.06c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
phh1; spc1
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (206476..208044, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene putative pyrimidine 5'-nucleotidase Neighboring gene miscRNA Neighboring gene putative oxidoreductase Neighboring gene putative COPII-coated vesicle-associated protein Erv46 Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis. Hu Y, et al. Int J Biochem Cell Biol, 2022 Nov. PMID 36174923
  2. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Mutavchiev DR, et al. Curr Biol, 2016 Nov 7. PMID 27746023, Free PMC Article
  3. Nuclear roles and regulation of chromatin structure by the stress-dependent MAP kinase Sty1 of Schizosaccharomyces pombe. Sansó M, et al. Mol Microbiol, 2011 Nov. PMID 21992435
  4. Rum1, an inhibitor of cyclin-dependent kinase in fission yeast, is negatively regulated by mitogen-activated protein kinase-mediated phosphorylation at Ser and Thr residues. Matsuoka K, et al. Eur J Biochem, 2002 Jul. PMID 12135491
  5. Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast. Kon N, et al. Mol Cell Biol, 1998 Dec. PMID 9819443, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
    Title: Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
  2. propose that the gas1-287 mutation causes longevity as the similar mechanism as cell wall stress depending on Pmk1 and Sty1 MAPK pathways
    Title: gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe.
  3. Sty1 and Atf1 were involved in regulating mitotic slowdown in Schizosaccharomyces pombe under nitrosative stress.
    Title: Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe.
  4. The fission yeast stress-activated protein kinase Sty1, a homolog of mammalian p38 MAP kinase, regulates localization of the Cdc42 polarity module.
    Title: Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.
  5. Data suggest that osmotic stress induces hyperphosphorylation of mitotic inducer cdr1 for several hours and cells delay division during same time period; this stress-induced hyperphosphorylation requires both cdr1 autophosphorylation and stress-activated protein kinase sty1. (cdr1 = serine/threonine protein kinase cdr1/nim1; sty1 = MAP kinase sty1)
    Title: Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.
  6. Data suggest that S. pombe 972 expressing a nonphosphorylatable Atf1 variant is more sensitive to oxidative stress because of impaired transcription of subset of stress genes whose expression is controlled by Pap1; in S. pombe 972 expressing phospho-mimicking Atf1 mutant, presence of Sty1 is completely dispensable. (Atf1 = transcription factor Atf1; Sty1 = MAP kinase Sty1; Pap1 = transcription factor Pap1)
    Title: Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.
  7. Threonine-monophosphorylated Sty1 displays a limited biological activity particularly at the transcriptional level.
    Title: Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.
  8. Data suggests that Sty1 activation promotes Pyp2 phosphorylation to increase the stability of the phosphatase. This MAPK-dependent Pyp2 stabilisation allows cells to attenuate MAPK signalling and resume cell division, once stresses have been dealt with.
    Title: Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase.
  9. Sty1 and PKA activity in stationary phase is essential for interaction between Sds23/Psp1/Moc1 and Ufd2.
    Title: Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.
  10. Data indicate that MAPKKK heteromer promotes stress signaling to the Spc1 MAPK.
    Title: Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables MAP kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of cytoplasmic translational initiation in response to stress IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osmosensory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of silent mating-type cassette heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic actomyosin contractile ring assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP kinase Sty1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    206476..208044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018244.2 → NP_592843.1  MAP kinase Sty1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592843.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09892
    Conserved Domains (2) summary
    smart00220
    Location:20 → 299
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07856
    Location:9 → 336
    STKc_Sty1_Hog1; Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAB35980.1

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