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cdc25 M phase inducer phosphatase Cdc25 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542632, updated on 7-Apr-2024

Summary

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Gene symbol
cdc25
Gene description
M phase inducer phosphatase Cdc25
Primary source
PomBase:SPAC24H6.05
Locus tag
SPAC24H6.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sal2
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Genomic context

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Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (479228..482556, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S9 Neighboring gene DNA replication pre-initiation complex subunit Sld3 Neighboring gene hexokinase 1 Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene cullin 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast. Keifenheim D, et al. Curr Biol, 2017 May 22. PMID 28479325, Free PMC Article
  2. A yeast mitotic activator sensitises the shoot apical meristem to become floral in day-neutral tobacco. Vojvodová P, et al. Planta, 2013 Oct. PMID 23897296
  3. MAPK mediated cell cycle regulation is associated with Cdc25 turnover in S. pombe after exposure to genotoxic stress. Sundaram G, et al. Cell Cycle, 2008 Feb 1. PMID 18235244
  4. cdc25+ functions as an inducer in the mitotic control of fission yeast. Russell P, et al. Cell, 1986 Apr 11. PMID 3955656
  5. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. Millar JB, et al. EMBO J, 1991 Dec. PMID 1756737, Free PMC Article

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that cell size in S. pombe is regulated by a third strategy: the size-dependent expression of the mitotic activator Cdc25. cdc25 transcript levels are regulated such that smaller cells express less Cdc25 and larger cells express more Cdc25, creating an increasing concentration of Cdc25 as cells grow and providing a mechanism for cells to trigger cell division when they reach a threshold concentration of Cdc25.
    Title: Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast.
  2. Spcdc25 expression causes earlier flowering competence of shoot apical meristerm in transgenic tobacco.
    Title: A yeast mitotic activator sensitises the shoot apical meristem to become floral in day-neutral tobacco.
  3. The cell cycle phosphatase Cdc25 is a possible candidate to carry out observed arsenate reductase activity.
    Title: Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.
  4. show that these three sites have a role in the negative regulation of Cdc25 following replication arrest
    Title: Carboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast.
  5. these data suggest that Hsp9 has dual functions in stress adaptation and regulating a G2-M checkpoint by the Cdc25 inactivation; this differs from S. cerevisiae HSP12, which maintains cell membrane stability under stress conditions.
    Title: Small heat-shock protein Hsp9 has dual functions in stress adaptation and stress-induced G2-M checkpoint regulation via Cdc25 inactivation in Schizosaccharomyces pombe.
  6. The alp1-1315 mutation of the tubulin-folding cofactor D gene delays the mitosis initiation in cdc25-22 mutant cells of Schizosaccharomyces pombe
    Title: [The alp1-1315 mutation of the tubulin-folding cofactor D gene delays the mitosis initiation in cdc25-22 mutant cells of Schizosaccharomyces pombe].
  7. Mek1 acts independently of Cds1 to phosphorylate Cdc25, and this phosphorylation is required to trigger cell cycle arrest.
    Title: The fission yeast meiotic checkpoint kinase Mek1 regulates nuclear localization of Cdc25 by phosphorylation.
  8. Cdc25 interacts with the MAP kinase Sty1 and prevents mitotic entry in S. pombe cells following exposure to cigarette smoke extract.
    Title: MAPK mediated cell cycle regulation is associated with Cdc25 turnover in S. pombe after exposure to genotoxic stress.
  9. Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.
    Title: Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.
  10. Dominant mutations in the Schizosaccharomyces pombe spindle pole body (SPB) component Cut12 enable cdc25.22 mutants to overcome a G2 arrest.
    Title: Suppression of the Schizosaccharomyces pombe cut12.1 cell-cycle defect by mutations in cdc25 and genes involved in transcriptional and translational control.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 cell size control checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/MI transition of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size NAS
Non-traceable Author Statement
more info
  
involved_in response to mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
M phase inducer phosphatase Cdc25
NP_001342797.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    479228..482556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355978.1 → NP_001342797.1  M phase inducer phosphatase Cdc25 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06652
    Conserved Domains (1) summary
    COG5105
    Location:108 → 596
    MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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