cdc42 Rho family GTPase Cdc42 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: cdc42
Gene description: Rho family GTPase Cdc42
Locus tag: SPAC110.03
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc42 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003424.3 (1916054..1917656)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
Title: Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.
Title: Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.
Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.
Title: Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.
Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
Title: Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
Title: Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
Cdc42 activation pattern by GEF1 and Scd1 promotes different events during cytokinesis.
Title: Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
cells evolved highly robust symmetry-breaking mechanisms that rely on feedback amplification of local Cdc42 activity. In turn, local Cdc42 activity favors Cdc42 accumulation because active Cdc42 is poorly mobile relative to the inactive form.
Title: Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry.
Tea4-PP1 landmark promotes local Cdc42 activation and growth both through Cdc42 GEF recruitment and by creating a local trough in a Cdc42 GAP.
Title: The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
Regulation of Cdc42 activity and localization and polarized cell growth in Schizosaccharomyces pombe. [Review]
Title: Cdc42 regulates polarized growth and cell integrity in fission yeast.
REVIEW: Cdc42 dynamics in the control of fission yeast cell polarization
Title: Role of Cdc42 dynamics in the control of fission yeast cell polarization.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	EXP Inferred from Experiment more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in bipolar cell growth	EXP Inferred from Experiment more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic nuclear membrane biogenesis	ISO Inferred from Sequence Orthology more info
involved_in modification of synaptic structure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mating projection assembly	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of mating projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of beta-glucan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity regulating cell shape	EXP Inferred from Experiment more info	PubMed
involved_in regulation of exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signaling	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
part_of Cdc42 GTPase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex of cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex of growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical dynamic polarity patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in lateral cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane of cell tip	EXP Inferred from Experiment more info	PubMed
is_active_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rho family GTPase Cdc42

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

1916054..1917656

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018970.2 → NP_593536.1 Rho family GTPase Cdc42 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593536.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q01112

Conserved Domains (2) summary

smart00174
Location:6 → 179

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family