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rad22 DNA recombination protein Rad22 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543086, updated on 13-Mar-2024

Summary

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Gene symbol
rad22
Gene description
DNA recombination protein Rad22
Locus tag
SPAC30D11.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad22A
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1099489..1101583, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene hemolysin-III family protein Neighboring gene 60S ribosomal protein L38 Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene protein Cwf19 Neighboring gene Lsd1/2 complex PHD finger domain-containing protein Phf2 Neighboring gene DNA endonuclease III

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rad22 protein, a rad52 homologue in Schizosaccharomyces pombe, binds to DNA double-strand breaks. Kim WJ, et al. J Biol Chem, 2000 Nov 10. PMID 10956666
  2. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae. Ostermann K, et al. Nucleic Acids Res, 1993 Dec 25. PMID 8290356, Free PMC Article
  3. Shelterin components mediate genome reorganization in response to replication stress. Mizuguchi T, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28490498, Free PMC Article
  4. Rad52 protein function study by fluorescence tagging. Bordeianu G, et al. Rev Med Chir Soc Med Nat Iasi, 2013 Apr-Jun. PMID 24340529
  5. [Molecular basis of the formation and branch migration of Holliday recombination intermediates mediated by eukaryotic recombinases]. Murayama Y, et al. Tanpakushitsu Kakusan Koso, 2008 Sep. PMID 18788459

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.
    Title: DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.
  2. Rad52 competes with Sgs1 for DNA end binding and inhibits Sgs1 translocation along DNA, identifying a role for Rad52 in limiting ssDNA generated by end resection.
    Title: Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast.
  3. Rad52 protein function study by fluorescne tagging.Rad22 protein tagging,a S. pombe is a Rad52 homologue.Presence of tagged Rad22 protein was confirmed by Western-blot and fluorescence microscopy.
    Title: Rad52 protein function study by fluorescence tagging.
  4. Rad22 plays dual roles in regulating meiotic recombination: activating Rad51 and inhibiting Dmc1.
    Title: Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.
  5. mediates the formation and branch migration of Holliday recombination intermediates. (review)
    Title: [Molecular basis of the formation and branch migration of Holliday recombination intermediates mediated by eukaryotic recombinases].
  6. The most important function of Rad22 and Rti1 in S. pombe meiosis is repair of double-strand breaks with involvement of the sister chromatids.
    Title: The Rad52 homologs Rad22 and Rti1 of Schizosaccharomyces pombe are not essential for meiotic interhomolog recombination, but are required for meiotic intrachromosomal recombination and mating-type-related DNA repair.
  7. Rad22 can promote strand invasion to form a D-loop that can be cleaved by Mus81
    Title: DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.
  8. Gel-filtration experiments and electron microscopic analyses indicate self-association of Rad22A and Rad22B and the formation of multimeric structure.
    Title: Schizosaccharomyces pombe Rad22A and Rad22B have similar biochemical properties and form multimeric structures.
  9. rad54 and the RAD52 orthologs rad22A and rad22B are epistatic for the repair of double-strand breaks in DNA.
    Title: Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables damaged DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombinase assembly NAS
Non-traceable Author Statement
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gene conversion at mating-type locus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating type switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic recombination-dependent replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing EXP
Inferred from Experiment
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stalled replication fork localization to nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA recombination protein Rad22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1099489..1101583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018603.2 → NP_593207.1  DNA recombination protein Rad22 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593207.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36592
    Conserved Domains (1) summary
    COG5055
    Location:1 → 399
    RAD52; Recombination DNA repair protein (RAD52 pathway) [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version

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