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Gdnf glial cell derived neurotrophic factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25453, updated on 3-Feb-2019

Summary

Official Symbol
Gdnfprovided by RGD
Official Full Name
glial cell derived neurotrophic factorprovided by RGD
Primary source
RGD:2677
See related
Ensembl:ENSRNOG00000012819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
gndf
Summary
neurotrophic factor specific for midbrain dopamine neurons; binds to GDNFR-alpha and mediates activation of the Ret protein tyrosine kinase receptor [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 11.0), Liver (RPKM 10.9) and 8 other tissues See more
Orthologs

Genomic context

See Gdnf in Genome Data Viewer
Location:
2q16
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (56884181..56912964)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (76896991..76922471)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349958 Neighboring gene similar to ribosomal protein S9 Neighboring gene uncharacterized LOC103691480 Neighboring gene WD repeat domain 70 Neighboring gene mitochondrial cardiolipin hydrolase pseudogene Neighboring gene nucleoporin 155

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glial cell-derived neurotrophic factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
dorsal spinal cord development IEA
Inferred from Electronic Annotation
more info
 
dorsal spinal cord development ISO
Inferred from Sequence Orthology
more info
 
embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 
enteric nervous system development ISO
Inferred from Sequence Orthology
more info
 
enteric nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
metanephros development ISO
Inferred from Sequence Orthology
more info
 
metanephros development ISS
Inferred from Sequence or Structural Similarity
more info
 
midbrain development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
organ induction ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
 
peristalsis IEA
Inferred from Electronic Annotation
more info
 
peristalsis ISO
Inferred from Sequence Orthology
more info
 
peristalsis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ureteric bud formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ureteric bud formation ISS
Inferred from Sequence or Structural Similarity
more info
 
postganglionic parasympathetic fiber development IEA
Inferred from Electronic Annotation
more info
 
postganglionic parasympathetic fiber development ISO
Inferred from Sequence Orthology
more info
 
postganglionic parasympathetic fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane organization IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine uptake involved in synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine uptake involved in synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
 
regulation of morphogenesis of a branching structure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of ureteric bud formation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
sympathetic nervous system development IEA
Inferred from Electronic Annotation
more info
 
sympathetic nervous system development ISO
Inferred from Sequence Orthology
more info
 
sympathetic nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
ureteric bud formation IEA
Inferred from Electronic Annotation
more info
 
ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glial cell line-derived neurotrophic factor
Names
ATF
Glial cell line derived neutrophic factor
astrocyte-derived trophic factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019139.1NP_062012.1  glial cell line-derived neurotrophic factor precursor

    See identical proteins and their annotated locations for NP_062012.1

    Status: PROVISIONAL

    Source sequence(s)
    L15305
    UniProtKB/Swiss-Prot
    Q07731
    UniProtKB/TrEMBL
    A7UGJ1
    Related
    ENSRNOP00000044012.2, ENSRNOT00000041288.2
    Conserved Domains (1) summary
    pfam00019
    Location:116210
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    56884181..56912964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232010.3XP_006232072.1  glial cell line-derived neurotrophic factor isoform X3

    Conserved Domains (1) summary
    pfam00019
    Location:145239
    TGF_beta; Transforming growth factor beta like domain
  2. XM_006232011.3XP_006232073.1  glial cell line-derived neurotrophic factor isoform X4

    Conserved Domains (1) summary
    pfam00019
    Location:119213
    TGF_beta; Transforming growth factor beta like domain
  3. XM_008760756.2XP_008758978.1  glial cell line-derived neurotrophic factor isoform X1

    Conserved Domains (1) summary
    pfam00019
    Location:221315
    TGF_beta; Transforming growth factor beta like domain
  4. XM_008760757.2XP_008758979.1  glial cell line-derived neurotrophic factor isoform X2

    Conserved Domains (1) summary
    pfam00019
    Location:195289
    TGF_beta; Transforming growth factor beta like domain

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    52510468..52532694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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