Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj8provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 8provided by RGD
Primary source: RGD:2960
See related: Ensembl:ENSRNOG00000013463 AllianceGenome:RGD:2960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kir6.1; UKATP1; uKATP-1
Summary: Enables ATP binding activity; inorganic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in intracellular membrane-bounded organelle and sarcolemma. Part of inward rectifying potassium channel. Colocalizes with mitochondrion. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 172.2), Uterus (RPKM 96.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (177240692..177246548, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (175508908..175515829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176783287..176789143, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KATP Opener Attenuates Diabetic-Induced Muller Gliosis and Inflammation by Modulating Kir6.1 in Microglia.
Title: KATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia.
it can be concluded that mitoKATP channels regulate mitochondrial dynamics to participate in rotenone-induced Parkinson's disease mainly attributes to the pore subunits of Kir6.1.
Title: Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease.
In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age.
Title: Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.
both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations.
Title: Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Our results suggest that pretreatment with 0.5 MAC sevoflurane is as effective as IPC against intestinal ischemia-reperfusion injury. The activation of PKC and mKATP may be involved in the protective mechanisms of SPC.
Title: Sevoflurane Preconditioning Reduces Intestinal Ischemia-Reperfusion Injury: Role of Protein Kinase C and Mitochondrial ATP-Sensitive Potassium Channel.
Suggest that the increase in KATP channel subunits, SUR2 and Kir6.1, in the rostral ventrolateral medulla may be responsible for the greater sympathetic outflow and pressor effect of hydroxylamine in Ad-cystathionine beta-synthetase injected rats.
Title: Gene transfer of cystathionine β-synthase into RVLM increases hydrogen sulfide-mediated suppression of sympathetic outflow via KATP channel in normotensive rats.
ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant
Title: ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant.
Kir6.1 overactivity in vascular muscle can lead directly to reduced vascular contractility and lower blood pressure.
Title: Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.
Data indicate that activation of mitoK(ATP) channel decreased the latency time of the transjunctional currents by 50%.
Title: Opening of astrocytic mitochondrial ATP-sensitive potassium channels upregulates electrical coupling between hippocampal astrocytes in rat brain slices.
Tempol attenuates the exercise pressor reflex in rats with ligated femoral arteries via effects on K(ATP) channels.
Title: Blockade of ATP-sensitive potassium channels prevents the attenuation of the exercise pressor reflex by tempol in rats with ligated femoral arteries.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP-activated inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-activated inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-activated inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfonylurea receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrioventricular node cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac pacemaker cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive gliosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to resveratrol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic assembly at neuromuscular junction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of inward rectifying potassium channel	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of potassium ion-transporting ATPase complex	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 8

Names: Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017099.4 → NP_058795.3 ATP-sensitive inward rectifier potassium channel 8

See identical proteins and their annotated locations for NP_058795.3

Status: PROVISIONAL

Source sequence(s)

D42145

UniProtKB/Swiss-Prot

Q63664, Q9JM49, Q9JM50

UniProtKB/TrEMBL

A6IMU7, Q6AYX1

Related

ENSRNOP00000018057.3, ENSRNOT00000018057.6

Conserved Domains (2) summary

pfam01007
Location:37 → 184

IRK; Inward rectifier potassium channel

pfam17655
Location:191 → 363

IRK_C; Inward rectifier potassium channel C-terminal domain