P2rx1 purinergic receptor P2X 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2rx1provided by RGD
Official Full Name: purinergic receptor P2X 1provided by RGD
Primary source: RGD:3240
See related: Ensembl:ENSRNOG00000017606 AllianceGenome:RGD:3240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2XMR
Summary: Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and suramin binding activity. Involved in several processes, including glutamatergic synaptic transmission; neuronal action potential; and regulation of cytosolic calcium ion concentration. Located in membrane raft; neuron projection; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic active zone membrane. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 76.9), Spleen (RPKM 54.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (58117107..58132167)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (57618586..57633648)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (59566268..59581328)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Indicate a predominant role for P2X1R and P2X7R in the control of glomerular hemodynamics in ANG II hypertension.
Title: Physiopathological implications of P2X(1) and P2X(7) receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension.
Study demonstrated that P2X1 receptor-mediated calcium ion influx triggered by DA-9801 potentiated the Nerve Growth Factor-induced neurite outgrowth. The results obtained in this study imply a possible relationship between P2X1 and neuroregeneration.
Title: P2X1 Receptor-Mediated Ca(2+) Influx Triggered by DA-9801 Potentiates Nerve Growth Factor-Induced Neurite Outgrowth.
work identified that in major arteries of rat cerebral circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4 receptors subunits.
Title: Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries.
The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
P2X1, P2X2, P2X3, and P2X4 receptor subunits are expressed differently in rat nodose ganglion neurons
Title: Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons.
heteromeric P2X1/4Rs contribute to the sustained component of the purinergic-mediated vasoconstriction in rat middle cerebral arteries.
Title: ATP-evoked sustained vasoconstrictions mediated by heteromeric P2X1/4 receptors in cerebral arteries.
Trigeminal ganglion neurons functionally express P2X, P2X, and P2X receptors and that these receptors are involved in the mediation of not only nociceptive but also neuropathic pain in the orofacial area.
Title: Expression of P2X₁ and P2X₄ receptors in rat trigeminal ganglion neurons.
analysis of involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor
Title: Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.
The P2X1 and P2X3 subunits are detected in neuropils in the superficial layer of the rat dorsal horn.
Title: Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
evidence that 2 types of purinoreceptors are functional in renal vascular smooth muscle cells: monomeric P2X1 receptors and heteromeric P2X1/P2X4 receptors
Title: Purinoreceptor-mediated current in myocytes from renal resistance arteries.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ligand-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables suramin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insemination	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin secretion by platelet	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2X purinoceptor 1

Names: ATP receptor; P2X1; RP-2 protein; purinergic receptor P2X, ligand-gated ion channel, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142367.2 → NP_001135839.1 P2X purinoceptor 1 isoform 2

See identical proteins and their annotated locations for NP_001135839.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice junction in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC061742, X80477

UniProtKB/TrEMBL

A0A8I5Y0C5, B7U2F3

Conserved Domains (1) summary

cl02993
Location:1 → 341

P2X_receptor; ATP P2X receptor
NM_001285415.1 → NP_001272344.1 P2X purinoceptor 1 isoform 3

See identical proteins and their annotated locations for NP_001272344.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC061742, X80477

UniProtKB/TrEMBL

A0A0G2K5F9, A0A8I5Y0C5, A6HGH4, Q9JIF8

Related

ENSRNOP00000073411.1, ENSRNOT00000088245.2

Conserved Domains (1) summary

cl02993
Location:1 → 341

P2X_receptor; ATP P2X receptor
NM_012997.3 → NP_037129.1 P2X purinoceptor 1 isoform 1

See identical proteins and their annotated locations for NP_037129.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC061742, X80477

UniProtKB/Swiss-Prot

P47824

UniProtKB/TrEMBL

A0A8I5Y0C5, A6HGH3

Related

ENSRNOP00000024068.4, ENSRNOT00000024068.7

Conserved Domains (1) summary

TIGR00863
Location:1 → 368

P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

58117107..58132167

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085284.2 → XP_038941212.1 P2X purinoceptor 1 isoform X1

Conserved Domains (1) summary

cl02993
Location:1 → 266

P2X_receptor; ATP P2X receptor