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Rab3a RAB3A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 25531, updated on 13-Aug-2019

Summary

Official Symbol
Rab3aprovided by RGD
Official Full Name
RAB3A, member RAS oncogene familyprovided by RGD
Primary source
RGD:3528
See related
Ensembl:ENSRNOG00000019433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RAB3
Summary
regulated synaptic vesicle endocytosis [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1072.2), Heart (RPKM 150.1) and 4 other tissues See more
Orthologs

Genomic context

See Rab3a in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20435098..20439206, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (20292166..20296274, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348390 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene phosphodiesterase 4C Neighboring gene IQ motif containing N

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP-dissociation inhibitor binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
myosin V binding IEA
Inferred from Electronic Annotation
more info
 
myosin V binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab protein signal transduction IC
Inferred by Curator
more info
PubMed 
acrosomal vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
evoked neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
evoked neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
lysosome localization IEA
Inferred from Electronic Annotation
more info
 
maintenance of presynaptic active zone structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of presynaptic active zone structure ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 
plasma membrane repair ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of regulated secretory pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 
regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of short-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle fusion to presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle priming IDA
Inferred from Direct Assay
more info
PubMed 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
respiratory system process ISO
Inferred from Sequence Orthology
more info
PubMed 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
sensory perception of touch IEA
Inferred from Electronic Annotation
more info
 
sensory perception of touch ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle maturation IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle maturation ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
anchored component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
PubMed 
anchored component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular organelle IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic active zone ISO
Inferred from Sequence Orthology
more info
PubMed 
presynaptic active zone ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-3A
Names
Ras-related small GTP binding protein 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013018.2NP_037150.2  ras-related protein Rab-3A

    See identical proteins and their annotated locations for NP_037150.2

    Status: PROVISIONAL

    Source sequence(s)
    BC087580
    UniProtKB/Swiss-Prot
    P63012
    Related
    ENSRNOP00000026392.3, ENSRNOT00000026391.6
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    20435098..20439206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    18876401..18880512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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