Rab3a RAB3A, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab3aprovided by RGD
Official Full Name: RAB3A, member RAS oncogene familyprovided by RGD
Primary source: RGD:3528
See related: Ensembl:ENSRNOG00000019433 AllianceGenome:RGD:3528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RAB3
Summary: Enables several functions, including ATPase binding activity; GTP binding activity; and protein C-terminus binding activity. Involved in regulation of secretion by cell; regulation of synaptic vesicle priming; and synaptic vesicle cycle. Located in several cellular components, including cytosol; secretory vesicle; and terminal bouton. Part of protein-containing complex. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1072.2), Heart (RPKM 150.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18718164..18722273, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18684185..18688297, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20435098..20439206, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab3a attenuates spinal cord injury by mediating vesicle release.
Title: Rab3a attenuates spinal cord injury by mediating vesicle release.
Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons.
Title: Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons.
analysis of crystal structures and biochemical analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes, revealing how Rabphilin-3A C2 domains operate in cooperation with PIP2/Ca(2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the complete SNARE complex
Title: Structural characterization of the Rabphilin-3A-SNAP25 interaction.
This work has shed new light on the molecular mechanism for Rab3 and synaptotamin regulation of neurotransmitter release.
Title: Rab3A Inhibition of Ca(2+) -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I.
Rab3A-binding site on C2A domain of synaptotagmin I
Title: Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism.
discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release.
Title: Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.
Rab3A has been found to be a novel interacting protein of synaptotagmin I. Rab3A binds to synaptotagmin I in a Ca2+-independent manner.
Title: Rab3A is a new interacting partner of synaptotagmin I and may modulate synaptic membrane fusion through a competitive mechanism.
the Rab3A cycle is coupled with the activation of Munc13-1 via RIM, which accounts for the regulation of secretion by Rab3A.
Title: Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.
Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles
Title: Myosin5a tail associates directly with Rab3A-containing compartments in neurons.
Selective modulation of the GTP/GDP switch mechanism of Rab27b impairs synaptic vesicle recycling and suggests that Rab27b, in concert with Rab3a, is involved in synaptic vesicle exocytosis.
Title: Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130738 (e-PCR)
- UniSTS:214022

RH133798 (e-PCR)
- UniSTS:217081

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IC Inferred by Curator more info	PubMed
involved_in acrosomal vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in evoked neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in evoked neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of presynaptic active zone structure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of presynaptic active zone structure	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane repair	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulated secretory pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of regulated secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma membrane repair	IEA Inferred from Electronic Annotation more info
involved_in regulation of plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic dense core granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic dense core granule exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle priming	IDA Inferred from Direct Assay more info	PubMed
involved_in respiratory system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of touch	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic vesicle maturation	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-3A

Names: Ras-related small GTP binding protein 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.